Glioblastoma as an age-related neurological disorder in adults.

Autor:	Kim M; Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois, USA.; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Ladomersky E; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Mozny A; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Kocherginsky M; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., O'Shea K; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Reinstein ZZ; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Zhai L; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Bell A; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Lauing KL; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Bollu L; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Rabin E; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Dixit K; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Kumthekar P; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Platanias LC; Department of Medicine, Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Hou L; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Zheng Y; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Wu J; Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Zhang B; Department of Medicine, Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Hrachova M; Division of Neuro-Oncology, Department of Neurology, Mayo Clinic, Phoenix, Arizona, USA., Merrill SA; Division of Neuro-Oncology, Department of Neurology, Mayo Clinic, Phoenix, Arizona, USA., Mrugala MM; Division of Neuro-Oncology, Department of Neurology, Mayo Clinic, Phoenix, Arizona, USA., Prabhu VC; Department of Neurological Surgery, Loyola University Medical Center, Maywood, Illinois, USA., Horbinski C; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., James CD; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Yamini B; Department of Neurological Surgery, University of Chicago Medical Center & Biological Sciences, Chicago, Illinois, USA., Ostrom QT; Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA., Johnson MO; Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA., Reardon DA; Dana-Farber/Harvard Cancer Center, Harvard Medical School, Boston, Massachusetts, USA., Lukas RV; Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Wainwright DA; Department of Neurological Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Medicine, Division of Hematology-Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.; Department of Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Jazyk:	angličtina
Zdroj:	Neuro-oncology advances [Neurooncol Adv] 2021 Sep 04; Vol. 3 (1), pp. vdab125. Date of Electronic Publication: 2021 Sep 04 (Print Publication: 2021).
DOI:	10.1093/noajnl/vdab125
Abstrakt:	Background: Advanced age is a major risk factor for the development of many diseases including those affecting the central nervous system. Wild-type isocitrate dehydrogenase glioblastoma (IDH wt GBM) is the most common primary malignant brain cancer and accounts for ≥90% of all adult GBM diagnoses. Patients with IDH wt GBM have a median age of diagnosis at 68-70 years of age, and increasing age is associated with an increasingly worse prognosis for patients with this type of GBM. Methods: The Surveillance, Epidemiology, and End Results, The Cancer Genome Atlas, and the Chinese Glioma Genome Atlas databases were analyzed for mortality indices. Meta-analysis of 80 clinical trials was evaluated for log hazard ratio for aging to tumor survivorship. Results: Despite significant advances in the understanding of intratumoral genetic alterations, molecular characteristics of tumor microenvironments, and relationships between tumor molecular characteristics and the use of targeted therapeutics, life expectancy for older adults with GBM has yet to improve. Conclusions: Based upon the results of our analysis, we propose that age-dependent factors that are yet to be fully elucidated, contribute to IDH wt GBM patient outcomes. (© The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.)
Databáze:	MEDLINE
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