Local Ancestry to Identify Selection in Response to Trypanosome Infection in Baoulé x Zebu Crossbred Cattle in Burkina Faso.

Autor:	Yougbaré B; Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria.; Institut de l'Environnement et de Recherches Agricoles (INERA), Ouagadougou, Burkina Faso., Ouédraogo D; Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria.; Institut du Développement Rural, Université Nazi Boni, Bobo-Dioulasso, Burkina Faso., Tapsoba ASR; Institut du Développement Rural, Université Nazi Boni, Bobo-Dioulasso, Burkina Faso., Soudré A; Unité de Formation et de Recherche en Sciences et Technologies, Université Norbert Zongo, Koudougou, Burkina Faso., Zoma BL; Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria.; Institut du Développement Rural, Université Nazi Boni, Bobo-Dioulasso, Burkina Faso., Orozco-terWengel P; School of Biosciences, Cardiff University, Cardiff, United Kingdom., Moumouni S; Institut de l'Environnement et de Recherches Agricoles (INERA), Ouagadougou, Burkina Faso., Ouédraogo-Koné S; Institut du Développement Rural, Université Nazi Boni, Bobo-Dioulasso, Burkina Faso., Wurzinger M; Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria., Tamboura HH; Institut de l'Environnement et de Recherches Agricoles (INERA), Ouagadougou, Burkina Faso., Traoré A; Institut de l'Environnement et de Recherches Agricoles (INERA), Ouagadougou, Burkina Faso., Mwai OA; International Livestock Research Institute (ILRI), Nairobi, Kenya., Sölkner J; Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria., Khayatzadeh N; Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria.; SUISAG, Sempach, Switzerland., Mészáros G; Department of Sustainable Agricultural Systems, University of Natural Resources and Life Sciences Vienna (BOKU), Vienna, Austria., Burger PA; Research Institute of Wildlife Ecology, Vetmeduni Vienna, Savoyenstraße 1, Vienna, Austria.
Jazyk:	angličtina
Zdroj:	Frontiers in genetics [Front Genet] 2021 Sep 27; Vol. 12, pp. 670390. Date of Electronic Publication: 2021 Sep 27 (Print Publication: 2021).
DOI:	10.3389/fgene.2021.670390
Abstrakt:	The genomes of crossbred (admixed) individuals are a mosaic of ancestral haplotypes formed by recombination in each generation. The proportion of these ancestral haplotypes in certain genomic regions can be responsible for either susceptibility or tolerance against pathogens, and for performances in production traits. Using a medium-density genomic marker panel from the Illumina Bovine SNP50 BeadChip, we estimated individual admixture proportions for Baoulé x Zebu crossbred cattle in Burkina Faso, which were tested for trypanosome infection by direct ELISA from blood samples. Furthermore, we calculated local ancestry deviation from average for each SNP across 29 autosomes to identify potential regions under selection in the trypanotolerant Baoulé cattle and their crossbreds. We identified significant deviation from the local average ancestry (above 5 and 10% genome-wide thresholds) on chromosomes 8 and 19 in the positive animals, while the negative ones showed higher deviation on chromosomes 6, 19, 21, and 22. Some candidate genes on chromosome 6 ( PDGFRA ) and chromosome 19 ( CDC6 ) have been found associated to trypanotolerance in West African taurines. Screening for F ST outliers in trypanosome positive/negative animals we detected seven variants putatively under selection. Finally, we identified a minimum set of highly ancestry informative markers for routine admixture testing. The results of this study contribute to a better understanding of the genetic basis of trypanotolerance in Baoulé cattle and their crossbreeds. Furthermore, we provide a small informative marker set to monitor admixture in this valuable indigenous breed. As such, our results are important for conserving the genetic uniqueness and trypanotolerance of Baoulé cattle, as well as for the improvement of Baoulé and Zebu crossbreds in specific community-based breeding programs. Competing Interests: NK was employed by company SUISAG, Switzerland. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Yougbaré, Ouédraogo, Tapsoba, Soudré, Zoma, Orozco-terWengel, Moumouni, Ouédraogo-Koné, Wurzinger, Tamboura, Traoré, Mwai, Sölkner, Khayatzadeh, Mészáros and Burger.)
Databáze:	MEDLINE
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