Chagas disease and SARS-CoV-2 coinfection does not lead to worse in-hospital outcomes.

Autor: Molina I; PROSICS Barcelona, Vall d'Hebron University Hospital, Passeig de la Vall d'Hebron, 119, 08035, Barcelona, Spain.; Instituto René Rachou-FIOCRUZ Minas, Av. Augusto de Lima, 1715, Belo Horizonte, Brazil., Marcolino MS; Department of Internal Medicine, Medical School and Telehealth Center, University Hospital, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena 190 Sala 246, Belo Horizonte, Brazil. milenamarc@ufmg.br.; Institute for Health Technology Assessment (IATS/ CNPq), Rua Ramiro Barcelos, 2359, Prédio 21 | Sala 507, Porto Alegre, Brazil. milenamarc@ufmg.br., Pires MC; Department of Statistics, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, ICEx, Sala 4071, Belo Horizonte, Brazil., Ramos LEF; Department of Statistics, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, ICEx, Sala 4071, Belo Horizonte, Brazil., Silva RT; Department of Statistics, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, ICEx, Sala 4071, Belo Horizonte, Brazil., Guimarães-Júnior MH; Hospital Marcio Cunha, Av. Tsunawaki Avenue, 41, Ipatinga, Brazil., de Oliveira IJR; Medical School, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil., de Carvalho RLR; Institute for Health Technology Assessment (IATS/ CNPq), Rua Ramiro Barcelos, 2359, Prédio 21 | Sala 507, Porto Alegre, Brazil., Nunes AGS; Hospital UNIMED BH, Av. Do Contorno, Belo Horizonte, 3097, Brazil., de Barros ALRM; Hospital Metropolitano Doutor Célio de Castro, Rua Dona Luiza, 311, Belo Horizonte, Brazil.; Faculdade de Ciências Médicas de Minas Gerais, Alameda Ezequiel Dias, 275, Belo Horizonte, MG, CEP 30130-100, Brazil., Scotton ALBA; Hospital Regional Antônio Dias, R. Maj. Gote, 1231, Patos de Minas, Brazil., Madureira AAC; Hospital Metropolitano Doutor Célio de Castro, Rua Dona Luiza, 311, Belo Horizonte, Brazil.; Faculdade de Ciências Médicas de Minas Gerais, Alameda Ezequiel Dias, 275, Belo Horizonte, MG, CEP 30130-100, Brazil., Farace BL; Hospital Risoleta Tolentino Neves, Rua das Gabirobas, 01, Belo Horizonte, Brazil., de Carvalho CA; Hospital João XXIII, Av. Professor Alfredo Balena, 400, Belo Horizonte, Brazil., Rodrigues FD; Hospital de Clínicas de Porto Alegre, Av. Ramiro Barcellos, 2350, Porto Alegre, Brazil., Anschau F; Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Av. Francisco Trein, 326, Porto Alegre, Brazil.; Grupo Hospitalar Conceição, Hospital Nossa Senhora da Conceição, Av. Francisco Trein, 326, Porto Alegre, Brazil., Botoni FA; Medical School, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil.; Hospital Julia Kubitschek, R. Dr. Cristiano Rezende, 2745, Belo Horizonte, Brazil., Nascimento GF; Hospital UNIMED BH, Av. Do Contorno, Belo Horizonte, 3097, Brazil., Duani H; Medical School, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil.; Internal Medicine Department, University Hospital, Universidade Federal de Minas Gerais, Av. Prof Alfredo Balena, 110, Belo Horizonte, Brazil., Guimarães HC; Hospital Risoleta Tolentino Neves, Rua das Gabirobas, 01, Belo Horizonte, Brazil., de Alvarenga JC; Hospital João XXIII, Av. Professor Alfredo Balena, 400, Belo Horizonte, Brazil., Moreira LB; Institute for Health Technology Assessment (IATS/ CNPq), Rua Ramiro Barcelos, 2359, Prédio 21 | Sala 507, Porto Alegre, Brazil.; Hospital de Clínicas de Porto Alegre, Av. Ramiro Barcellos, 2350, Porto Alegre, Brazil., Zandoná LB; Universidade do Vale do Taquari (UNIVATES), Av. Avelino Talini, 171, Lajeado, Brazil.; Hospital Bruno Born, Av. Benjamin Constant, 881, Lajeado, Brazil., de Almeida LF; Medical School, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil., Oliveira LM; Institute for Health Technology Assessment (IATS/ CNPq), Rua Ramiro Barcelos, 2359, Prédio 21 | Sala 507, Porto Alegre, Brazil.; Center for Research and Graduate Studies in Business Administration, Universidade Federal de Minas Gerais, Av. Presidente Antônio Carlos, 6627, Belo Horizonte, Brazil., Kopittke L; Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Av. Francisco Trein, 326, Porto Alegre, Brazil.; Grupo Hospitalar Conceição, Hospital Nossa Senhora da Conceição, Av. Francisco Trein, 326, Porto Alegre, Brazil., de Castro LC; Universidade do Vale do Taquari (UNIVATES), Av. Avelino Talini, 171, Lajeado, Brazil.; Hospital Bruno Born, Av. Benjamin Constant, 881, Lajeado, Brazil., Santos LEA; Hospital Regional Antônio Dias, R. Maj. Gote, 1231, Patos de Minas, Brazil.; Centro Universitário de Patos de Minas, R. Maj. Gote, 808, Patos de Minas, Brazil., de Souza Cabral MA; Medical School, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil.; Internal Medicine Department, University Hospital, Universidade Federal de Minas Gerais, Av. Prof Alfredo Balena, 110, Belo Horizonte, Brazil., Ferreira MAP; Hospital de Clínicas de Porto Alegre, Av. Ramiro Barcellos, 2350, Porto Alegre, Brazil., da Cunha Severino Sampaio N; Hospital Eduardo de Menezes, R. Dr. Cristiano Rezende, 2213, Belo Horizonte, Brazil., de Oliveira NR; Hospital Eduardo de Menezes, R. Dr. Cristiano Rezende, 2213, Belo Horizonte, Brazil., Assaf PL; Hospital Metropolitano Doutor Célio de Castro, Rua Dona Luiza, 311, Belo Horizonte, Brazil., Lopes SJTS; Hospital Julia Kubitschek, R. Dr. Cristiano Rezende, 2745, Belo Horizonte, Brazil.; Pontífica Universidade Católica de Minas Gerais, Av. Dom José Gaspar, 500, Belo Horizonte, Brazil., Fereguetti TO; Hospital Eduardo de Menezes, R. Dr. Cristiano Rezende, 2213, Belo Horizonte, Brazil., Dos Santos VB; Hospital Nossa Senhora da Conceição and Hospital Cristo Redentor, Av. Francisco Trein, 326, Porto Alegre, Brazil.; Grupo Hospitalar Conceição, Hospital Nossa Senhora da Conceição, Av. Francisco Trein, 326, Porto Alegre, Brazil., de Carvalho VEB; Hospital Julia Kubitschek, R. Dr. Cristiano Rezende, 2745, Belo Horizonte, Brazil.; Pontífica Universidade Católica de Minas Gerais, Av. Dom José Gaspar, 500, Belo Horizonte, Brazil., Ramires YC; Hospital Bruno Born, Av. Benjamin Constant, 881, Lajeado, Brazil., Ribeiro ALP; Department of Internal Medicine, Medical School and Telehealth Center, University Hospital, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena 190 Sala 246, Belo Horizonte, Brazil.; Institute for Health Technology Assessment (IATS/ CNPq), Rua Ramiro Barcelos, 2359, Prédio 21 | Sala 507, Porto Alegre, Brazil., Moscoso FAB; Medical School of Fundação Educacional do Município de Assis, Av. Getúlio Vargas, 1200, Assis, Brazil., Moura R; Hospital Balbino - Rede D`or São Luiz, R. Angélica Mota, 90, Rio de Janeiro, Brazil., Polanczyk CA; Institute for Health Technology Assessment (IATS/ CNPq), Rua Ramiro Barcelos, 2359, Prédio 21 | Sala 507, Porto Alegre, Brazil.; Hospital de Clínicas de Porto Alegre, Av. Ramiro Barcellos, 2350, Porto Alegre, Brazil.; Internal Medicine Department, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2359, Prédio 21 | Sala 507, Porto Alegre, Brazil., do Carmo Pereira Nunes M; Medical School, Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190, Belo Horizonte, Brazil.; Internal Medicine Department, University Hospital, Universidade Federal de Minas Gerais, Av. Prof Alfredo Balena, 110, Belo Horizonte, Brazil.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Oct 13; Vol. 11 (1), pp. 20289. Date of Electronic Publication: 2021 Oct 13.
DOI: 10.1038/s41598-021-96825-3
Abstrakt: Chagas disease (CD) continues to be a major public health burden in Latina America. Information on the interplay between COVID-19 and CD is lacking. Our aim was to assess clinical characteristics and in-hospital outcomes of patients with CD and COVID-19, and to compare it to non-CD patients. Consecutive patients with confirmed COVID-19 were included from March to September 2020. Genetic matching for sex, age, hypertension, diabetes mellitus and hospital was performed in a 4:1 ratio. Of the 7018 patients who had confirmed COVID-19, 31 patients with CD and 124 matched controls were included (median age 72 (64-80) years-old, 44.5% were male). At baseline, heart failure (25.8% vs. 9.7%) and atrial fibrillation (29.0% vs. 5.6%) were more frequent in CD patients than in the controls (p < 0.05). C-reactive protein levels were lower in CD patients compared with the controls (55.5 [35.7, 85.0] vs. 94.3 [50.7, 167.5] mg/dL). In-hospital management, outcomes and complications were similar between the groups. In this large Brazilian COVID-19 Registry, CD patients had a higher prevalence of atrial fibrillation and chronic heart failure compared with non-CD controls, with no differences in-hospital outcomes. The lower C-reactive protein levels in CD patients require further investigation.
(© 2021. The Author(s).)
Databáze: MEDLINE
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