Methylene tetrahydrofolate reductase (MTHFR) and vascular endothelial growth factor (VEGF) polymorphisms in Brazilian patients with Hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC).

Autor:	Carvalho SCR; Hospital Universitario Oswaldo Cruz, Faculdade de Medicina, Universidade de Pernambuco, Recife, PE, BR.; Instituto do Figado e Transplantes de Pernambuco, Recife, PE, BR., Vasconcelos LRS; Instituto Aggeu Magalhaes (IAM/Fiocruz), Recife, PE, BR., Fonseca LD; Oncologia Clinica, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., Carmo RF; Universidade Federal Vale do Sao Francisco - UNIVASF, Petrolina, PE, BR., Tomitão MT; Disciplina de Cirurgia do Aparelho Digestivo, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., Aroucha DCBL; Hospital Universitario Oswaldo Cruz, Faculdade de Medicina, Universidade de Pernambuco, Recife, PE, BR.; Instituto do Figado e Transplantes de Pernambuco, Recife, PE, BR., Pereira LMMB; Hospital Universitario Oswaldo Cruz, Faculdade de Medicina, Universidade de Pernambuco, Recife, PE, BR.; Instituto do Figado e Transplantes de Pernambuco, Recife, PE, BR., Stefano JT; Laboratorio de Gastroenterologia Clinica e Experimental (LIM-07), Divisao de Gastroenterologia Clinica e Hepatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., Ribeiro-Júnior U; Disciplina de Cirurgia do Aparelho Digestivo, Instituto do Cancer do Estado de Sao Paulo (ICESP), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., Oliveira CP; Laboratorio de Gastroenterologia Clinica e Experimental (LIM-07), Divisao de Gastroenterologia Clinica e Hepatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR., Carrilho FJ; Laboratorio de Gastroenterologia Clinica e Experimental (LIM-07), Divisao de Gastroenterologia Clinica e Hepatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.
Jazyk:	angličtina
Zdroj:	Clinics (Sao Paulo, Brazil) [Clinics (Sao Paulo)] 2021 Oct 11; Vol. 76, pp. e2881. Date of Electronic Publication: 2021 Oct 11 (Print Publication: 2021).
DOI:	10.6061/clinics/2021/e2881
Abstrakt:	Objective: The folate pathway is involved in hepatic carcinogenesis and angiogenesis. Polymorphisms in genes related to such processes, including methylene tetrahydrofolate reductase (MTHFR) and vascular endothelial growth factor (VEGF)] may play an important role in the development of hepatocellular carcinoma (HCC). The objective of this study was to evaluate MTHFR and VEGF polymorphisms in Brazilian patients with hepatitis C virus (HCV)-related HCC. Methods: A total of 119 patients diagnosed with confirmed HCC and HCV were included in the study. SNP genotyping assays were performed using real-time PCR. VEGFA (rs2010963, rs3025039, and rs833061) and MTHFRC677T (rs1801133, rs1801131) polymorphisms were evaluated. Results: The C alleles of MTHFR (rs1801131) and VEGF (rs2010963) were associated with protection against the development of multinodular HCC, while the T allele of MTHFR (rs1801133) was associated with a higher risk of multinodular presentation [p=0.04 OR 1.835 CI (1.022-3.297)]. Multivariate analysis revealed that the GG/GC genotypes of VEGF rs2010963 were independently associated with multinodular tumors at diagnosis (p=0.013; OR 4.78 CI (1.38-16.67)]. Conclusion: Our results suggest that these polymorphisms may increase the risk of rapid tumor progression in patients with HCV infection. This subgroup of patients with HCC and who present polymorphism is more likely to be diagnosed with multinodular disease and not be amenable to receiving curative treatments. These data must be validated in larger cohorts, and the screening intervals can be customized based on genetic history.
Databáze:	MEDLINE
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