Laminar distribution and arbor density of two functional classes of thalamic inputs to primary visual cortex.

Autor:	Zhuang J; Allen Institute for Brain Science, Seattle, WA 98109, USA. Electronic address: junz@alleninstitute.org., Wang Y; Allen Institute for Brain Science, Seattle, WA 98109, USA., Ouellette ND; Allen Institute for Brain Science, Seattle, WA 98109, USA., Turschak EE; Allen Institute for Brain Science, Seattle, WA 98109, USA., Larsen RS; Allen Institute for Brain Science, Seattle, WA 98109, USA., Takasaki KT; Allen Institute for Brain Science, Seattle, WA 98109, USA., Daigle TL; Allen Institute for Brain Science, Seattle, WA 98109, USA., Tasic B; Allen Institute for Brain Science, Seattle, WA 98109, USA., Waters J; Allen Institute for Brain Science, Seattle, WA 98109, USA., Zeng H; Allen Institute for Brain Science, Seattle, WA 98109, USA., Reid RC; Allen Institute for Brain Science, Seattle, WA 98109, USA.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2021 Oct 12; Vol. 37 (2), pp. 109826.
DOI:	10.1016/j.celrep.2021.109826
Abstrakt:	Motion/direction-sensitive and location-sensitive neurons are the two major functional types in mouse visual thalamus that project to the primary visual cortex (V1). It is under debate whether motion/direction-sensitive inputs preferentially target the superficial layers in V1, as opposed to the location-sensitive inputs, which preferentially target the middle layers. Here, by using calcium imaging to measure the activity of motion/direction-sensitive and location-sensitive axons in V1, we find evidence against these cell-type-specific laminar biases at the population level. Furthermore, using an approach to reconstruct axon arbors with identified in vivo response types, we show that, at the single-axon level, the motion/direction-sensitive axons project more densely to the middle layers than the location-sensitive axons. Overall, our results demonstrate that motion/direction-sensitive thalamic neurons project extensively to the middle layers of V1 at both the population and single-cell levels, providing further insight into the organization of thalamocortical projection in the mouse visual system. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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