The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis.

Autor: Harapan H; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia.; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia., Fajar JK; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Supriono S; Department of Internal Medicine, Division of Gastro-Entero-Hepatology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Soegiarto G; Department of Internal Medicine, Division of Allergy & Immunology, Universitas Airlangga, Surabaya, Indonesia., Wulandari L; Department of Pulmonology and Respiratory Medicine, Universitas Airlangga, Surabaya, Indonesia., Seratin F; Department of Paediatric, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia., Prayudi NG; Department of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Dewi DP; Faculty of Public Health, Universitas Indonesia, Depok, Indonesia., Monica Elsina MT; Faculty of Nursing, Universitas Indonesia, Depok, Indonesia., Atamou L; Faculty of Nursing, Universitas Indonesia, Depok, Indonesia., Wiranata S; Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia., Aprianto DP; Faculty of Public Health, Universitas Indonesia, Depok, Indonesia., Friska E; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia., Sari Firdaus DF; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia., Alaidin M; Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia., Wardhani FA; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia., Husnah M; Master Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia., Hidayati NW; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia., Hendriyanti Y; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia., Wardani K; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Evatta A; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Manugan RA; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Pradipto W; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Rahmawati A; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Tamara F; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Mahendra AI; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia., Nainu F; Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia., Santoso B; Department of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia., Irawan Primasatya CA; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia., Tjionganata N; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia., Budiman HA; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Jazyk: angličtina
Zdroj: Reviews in medical virology [Rev Med Virol] 2022 May; Vol. 32 (3), pp. e2304. Date of Electronic Publication: 2021 Oct 13.
DOI: 10.1002/rmv.2304
Abstrakt: The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) -125; 95% CI: -207, -43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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