Seasonality of tuberculosis in intermediate endemicity setting dominated by reactivation diseases in Hong Kong.

Autor: Lau LHW; Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong , China., Wong NS; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China., Leung CC; Hong Kong Tuberculosis, Chest and Heart Disease Association, Hong Kong, China., Chan CK; Tuberculosis and Chest Service, Centre for Health Protection, Department of Health, Hong Kong, China., Lau AKH; Department of Civil and Environmental Engineering, The Hong Kong University of Science and Technology, Hong Kong, China.; Division of Environment and Sustainability, The Hong Kong University of Science and Technology, Hong Kong, China., Tian L; School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China., Lee SS; Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China. sslee@cuhk.edu.hk.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Oct 12; Vol. 11 (1), pp. 20259. Date of Electronic Publication: 2021 Oct 12.
DOI: 10.1038/s41598-021-99651-9
Abstrakt: Summer-spring predominance of tuberculosis (TB) has been widely reported. The relative contributions of exogenous recent infection versus endogenous reactivation to such seasonality remains poorly understood. Monthly TB notifications data between 2005 and 2017 in Hong Kong involving 64,386 cases (41% aged ≥ 65; male-to-female ratio 1.74:1) were examined for the timing, amplitude, and predictability of variation of seasonality. The observed seasonal variabilities were correlated with demographics and clinical presentations, using wavelet analysis coupled with dynamic generalised linear regression models. Overall, TB notifications peaked annually in June and July. No significant annual seasonality was demonstrated for children aged ≤ 14 irrespective of gender. The strongest seasonality was detected in the elderly (≥ 65) among males, while seasonal pattern was more prominent in the middle-aged (45-64) and adults (30-44) among females. The stronger TB seasonality among older adults in Hong Kong suggested that the pattern has been contributed largely by reactivation diseases precipitated by defective immunity whereas seasonal variation of recent infection was uncommon.
(© 2021. The Author(s).)
Databáze: MEDLINE
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