RHAMM Is a Multifunctional Protein That Regulates Cancer Progression.

Autor: Messam BJ; Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, London, ON N6A 5C1, Canada., Tolg C; London Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, ON N6A 4L6, Canada., McCarthy JB; Masonic Cancer Center, Department of Laboratory Medicine and Pathology, Minneapolis, MN 55455, USA., Nelson AC; Masonic Cancer Center, Department of Laboratory Medicine and Pathology, Minneapolis, MN 55455, USA., Turley EA; London Regional Cancer Program, London Health Sciences Centre, Victoria Hospital, London, ON N6A 4L6, Canada.; Departments of Oncology, Biochemistry, and Surgery, Schulich School of Medicine, Western University, London, ON N6A 5C1, Canada.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2021 Sep 24; Vol. 22 (19). Date of Electronic Publication: 2021 Sep 24.
DOI: 10.3390/ijms221910313
Abstrakt: The functional complexity of higher organisms is not easily accounted for by the size of their genomes. Rather, complexity appears to be generated by transcriptional, translational, and post-translational mechanisms and tissue organization that produces a context-dependent response of cells to specific stimuli. One property of gene products that likely increases the ability of cells to respond to stimuli with complexity is the multifunctionality of expressed proteins. Receptor for hyaluronan-mediated motility (RHAMM) is an example of a multifunctional protein that controls differential responses of cells in response-to-injury contexts. Here, we trace its evolution into a sensor-transducer of tissue injury signals in higher organisms through the detection of hyaluronan (HA) that accumulates in injured microenvironments. Our goal is to highlight the domain and isoform structures that generate RHAMM's function complexity and model approaches for targeting its key functions to control cancer progression.
Databáze: MEDLINE
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