Elevated levels of serum CD5 antigen-like protein distinguish secondary progressive multiple sclerosis from other disease subtypes.

Autor: Kamma E; Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: emily.kamma@ubc.ca., Becquart P; Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: pierre.becquart@ubc.ca., Traboulsee A; Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: t.traboulsee@ubc.ca., Schabas A; Division of Neurology, Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: alice.schabas@vch.ca., Vavasour IM; Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: lees@phas.ubc.ca., Laule C; Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada; Department of Radiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, Canada; Department of Physics & Astronomy, Faculty of Science, University of British Columbia, Vancouver, Canada. Electronic address: claule@physics.ubc.ca., Vilariño-Güell C; Department of Medical Genetics, Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: carles@can.ubc.ca., Quandt JA; Department of Pathology & Laboratory Medicine, Faculty of Medicine, University of British Columbia, Vancouver, Canada; International Collaboration on Repair Discoveries (ICORD), Faculty of Medicine, University of British Columbia, Vancouver, Canada. Electronic address: jquandt@pathology.ubc.ca.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2021 Nov; Vol. 56, pp. 103269. Date of Electronic Publication: 2021 Sep 20.
DOI: 10.1016/j.msard.2021.103269
Abstrakt: CD5 antigen-like (CD5L) protein is a macrophage-secreted protein with roles in immunomodulation and lipid homeostasis. We compared serum CD5L levels in healthy controls to individuals diagnosed with clinically isolated syndrome, relapsing remitting (RR), secondary progressive (SP), and primary progressive (PP) multiple sclerosis (MS). CD5L was increased in SPMS relative to controls, RRMS, and PPMS. SPMS CD5L was associated with longer disease duration independent of age, sex, or disease severity. The positive relationship between CD5L and disease duration in SPMS suggests a chronic peripheral inflammatory profile compared to other subtypes, particularly PPMS, warranting investigation of functional roles for CD5L in MS.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
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