Chlamydia pneumoniae and Helicobacter pylori infections and immunological profile of community-dwelling older adults.

Autor: Noronha BP; Instituto René Rachou, Fundação Oswaldo Cruz, Fiocruz Minas, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil., Mambrini JVM; Instituto René Rachou, Fundação Oswaldo Cruz, Fiocruz Minas, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil. Electronic address: juliana.mambrini@fiocruz.br., Torres KCL; Instituto René Rachou, Fundação Oswaldo Cruz, Fiocruz Minas, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brazil; Universidade José do Rosário Vellano, UNIFENAS, Belo Horizonte, MG, Brazil., Martins-Filho OA; Instituto René Rachou, Fundação Oswaldo Cruz, Fiocruz Minas, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brazil. Electronic address: olindo.filho@fiocruz.br., Teixeira-Carvalho A; Instituto René Rachou, Fundação Oswaldo Cruz, Fiocruz Minas, Grupo Integrado de Pesquisas em Biomarcadores, Belo Horizonte, MG, Brazil. Electronic address: andrea.teixeira@fiocruz.br., Lima-Costa MF; Instituto René Rachou, Fundação Oswaldo Cruz, Fiocruz Minas, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil. Electronic address: lima.costa@fiocruz.br., Peixoto SV; Instituto René Rachou, Fundação Oswaldo Cruz, Fiocruz Minas, Núcleo de Estudos em Saúde Pública e Envelhecimento, Belo Horizonte, MG, Brazil; Universidade Federal de Minas Gerais, Escola de Enfermagem, Departamento de Gestão em Saúde, Belo Horizonte, MG, Brazil. Electronic address: sergio.peixoto@fiocruz.br.
Jazyk: angličtina
Zdroj: Experimental gerontology [Exp Gerontol] 2021 Dec; Vol. 156, pp. 111589. Date of Electronic Publication: 2021 Oct 09.
DOI: 10.1016/j.exger.2021.111589
Abstrakt: Chronic bacterial infections are associated with changes in the immunosenescence process and immunological biomarkers can assist in monitoring these changes. The identification of this immunological profile is important because Chlamydia pneumoniae (C. pneumoniae) and Helicobacter pylori (H. pylori) infections are important factors of morbidity and mortality among the older adults. This study aimed to identify changes in the immunological profile in the presence of C. pneumoniae and H. pylori infections among community-dwelling older adults. This is a cross-sectional study that used data from 1432 participants from the Bambuí Cohort Study of Aging, Minas Gerais, Brazil. The presence of immunoglobulin G (IgG) for C. pneumoniae and H. pylori was considered a dependent variable and assessed in the participants' serum using the enzyme-linked immunosorbent assay (ELISA). In assessing the immunological profile, the following inflammatory markers were considered: CXCL8, CXCL9, CXCL10, CCL2, CCL5, IL-1β, IL-6, IL-10, IL-12, TNF, and CRP. Associations were assessed by logistic regression, estimating odds ratios and confidence intervals (95%) using the Stata® V.13.1 software. The seroprevalence of anti-C. pneumoniae and anti-H. pylori antibodies was 55.9% and 70.3%, respectively. While high levels of anti-C. pneumoniae antibodies were associated with higher concentrations of CXCL10 and IL-10, higher levels of IL-1β and IL-6 were inversely associated with the titration of anti-H. pylori antibodies. The results characterize immunological profiles associated with these chronic infections and reinforce the potential effects of biomarkers on infections by these bacteria and on the immunosenescence process.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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