Agathadiol, a labdane diterpenoid from juniper berries, is a positive allosteric modulator of CB 1 R.

Autor: Salamone S; Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy., Appendino G; Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy., Khalili A; Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy., Pollastro F; Dipartimento di Scienze del Farmaco, Largo Donegani 2, 28100 Novara, Italy; PlantaChem Srls, via Amico Canobio 4/6, 28100 Novara, Italy. Electronic address: federica.pollastro@uniupo.it., Munoz E; Instituto Maimónides de Investigación Biomédica de Córdoba, av. de Menéndez Pidal, 14004 Córdoba, Spain; Departamento de Biología Celular, Fisiología e Inmunología, Campus de Menéndez Pidal, Universidad de Córdoba, 14071 Spain Córdoba, Spain; Hospital Universitario Reina Sofía, av. de Menéndez Pidal, s/n, 14004 Córdoba, Spain. Electronic address: fi1muble@uco.es., Unciti-Broceta JD; Emerald Health Biotechnology, Parque Científico Tecnológico Rabanales 21, Calle Cecilia Payne, 14014 Córdoba, Spain.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2021 Nov; Vol. 155, pp. 105059. Date of Electronic Publication: 2021 Oct 09.
DOI: 10.1016/j.fitote.2021.105059
Abstrakt: The neutral fraction of a juniper (Juniperus communis L.) berries acetone extract could positively modulate the activity of type 1 - cannabinoid receptor (CB 1 R). Bioactivity-directed fractionation identified the labdane diterpenoid agathadiol (4) as a positive allosteric modulator of CB 1 R, while closely related analogues were inactive. Agathadiol (4) is a minor constituent of juniper, but could be more conveniently obtained by semisynthesis from agathic acid (8), a major constituent of Manila copal.
(Published by Elsevier B.V.)
Databáze: MEDLINE
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