Volcanic ash-driven worsening of mucosal inflammation in an experimental colitis model.

Autor: Orsini Delgado ML; Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET y Universidad Nacional de La Plata, La Plata, Argentina. Electronic address: luorsini@gmail.com., Sambuelli A; Servicio de Enfermedades Inflamatorias, Hospital de Gastroenterología Bonorino Udaondo, Buenos Aires, Argentina. Electronic address: alicia.sambuelli@gmail.com., Negreira S; Servicio de Enfermedades Inflamatorias, Hospital de Gastroenterología Bonorino Udaondo, Buenos Aires, Argentina. Electronic address: negreirasilvia@hotmail.com., Gil A; Servicio de Enfermedades Inflamatorias, Hospital de Gastroenterología Bonorino Udaondo, Buenos Aires, Argentina. Electronic address: agil@intramed.net., D Elia L; Centro de Investigaciones Geológicas (CIG), CONICET y Universidad Nacional de La Plata, La Plata, Argentina. Electronic address: ldelia@cig.museo.unlp.edu.ar., Smaldini PL; Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET y Universidad Nacional de La Plata, La Plata, Argentina. Electronic address: psmaldini@biol.unlp.edu.ar., Docena GH; Instituto de Estudios Inmunológicos y Fisiopatológicos (IIFP), CONICET y Universidad Nacional de La Plata, La Plata, Argentina. Electronic address: guidoc@biol.unlp.edu.ar.
Jazyk: angličtina
Zdroj: Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2022 Jan 01; Vol. 292 (Pt B), pp. 118351. Date of Electronic Publication: 2021 Oct 09.
DOI: 10.1016/j.envpol.2021.118351
Abstrakt: Particulate matter exposure and related chemical changes in drinking water have been associated with health problems and inflammatory disorders. This study aimed to examine the effect of orally administered ash-water dilution on the gut of mice under normal and inflammatory conditions. Balb/c mice received ash-released soluble and dust-suspended components in the drinking water for 14 days. On day 7, animals were intrarectally instilled with TNBS in ethanol or flagellin from Salmonella typhimurium in PBS. At sacrifice, colon segments were collected and histologic damage, mRNA expression and cytokine levels in tissue were evaluated. In addition, these parameters were also evaluated in IL-10 null mice. We found that mice that received 5% w. fine-ash dilution in the drinking water worsened colitis signs. Weight loss, shortening of the colon, tissue edema with mucosa and submucosa cell infiltration and production of pro-inflammatory cytokines and chemokines were enhanced compared to control mice. A more pronounced inflammation was observed in IL-10 null mice. In addition, markers of NLRP3-dependent inflammasome activation were found in animals exposed to ash. In conclusion, ingestion of contaminated water with dust-suspended particulate matter enhanced the inflammatory response in the gut, probably due to alteration of the gut barrier and promoting an intense contact with the luminal content. This study critically appraises the response for fine particulate matter in uncommon illnesses reported for volcanic ash pollution. We suggest actions to enable better prediction and assessment the health impacts of volcanic eruptions.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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