Sex- and age- specific normal values of left ventricular functional and myocardial mass parameters using threshold-based trabeculae quantification.

Autor: Gregor Z; Heart and Vascular Center of Semmelweis University, Budapest, Hungary., Kiss AR; Heart and Vascular Center of Semmelweis University, Budapest, Hungary., Szabó LE; Heart and Vascular Center of Semmelweis University, Budapest, Hungary., Tóth A; Heart and Vascular Center of Semmelweis University, Budapest, Hungary., Grebur K; Heart and Vascular Center of Semmelweis University, Budapest, Hungary., Horváth M; Heart and Vascular Center of Semmelweis University, Budapest, Hungary., Dohy Z; Heart and Vascular Center of Semmelweis University, Budapest, Hungary., Merkely B; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.; Department of Sports Medicine, Semmelweis University, Budapest, Hungary., Vágó H; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.; Department of Sports Medicine, Semmelweis University, Budapest, Hungary., Szűcs A; Heart and Vascular Center of Semmelweis University, Budapest, Hungary.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Oct 12; Vol. 16 (10), pp. e0258362. Date of Electronic Publication: 2021 Oct 12 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0258362
Abstrakt: Background: The threshold-based (TB) trabeculated and papillary muscle mass (TPM) quantification method for cardiac MRI (CMR) calculates different values than conventional contouring techniques. We aimed to identify the sex- and age-related normal reference ranges for left ventricular (LV) myocardial mass values, volumetric and functional parameters and the correspondence of these parameters using the TB method.
Methods: Healthy European adults (n = 200, age: 39.4 ± 12 years, males: 100) were examined with CMR and evaluated with a TB postprocessing method. They were stratified by sex and age (Group A: 18-29, Group B: 30-39, Group C: 40-49, Group D: >50 years). The calculated parameters were indexed to body surface area (i).
Results: The normal reference ranges for the studied parameters were assessed in each age group. Significant biometric differences in LV parameters and mass-to-volume ratios were found between males and females, and the left ventricular compacted myocardial mass (LVCMi) and TPMi differences remained significant after stratification by age. Unlike other LV volumetric and functional parameters and mass-to-volume ratios, the TPMi, the LVCMi and the TPMi-to-LVCMi ratio did not differ among age groups in males or females. This finding was strengthened by the lack of correlation between TPMi and age.
Conclusions: Age- and sex-related normal reference ranges for LV volumetric and functional parameters and LVCMi and TPMi values were established using a TB postprocessing method. TPMi, LVCMi and their ratio did not change over time. The TPMi-to-LVCMi and the mass-to-volume ratios might have clinical utility in the differential diagnosis of conditions with LV hypertrabeculation.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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