Clinical Practice Guidelines for Pre-Analytical Procedures of Plasma Epidermal Growth Factor Receptor Variant Testing.
| Autor: | Shin S; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea., Woo HI; Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Kim JW; Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., M D YK; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea., Lee KA; Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. |
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| Jazyk: | angličtina |
| Zdroj: | Annals of laboratory medicine [Ann Lab Med] 2022 Mar 01; Vol. 42 (2), pp. 141-149. |
| DOI: | 10.3343/alm.2022.42.2.141 |
| Abstrakt: | Standardization of cell-free DNA (cfDNA) testing processes is necessary to obtain clinically reliable results. The pre-analytical phase of cfDNA testing greatly influences the results because of the low proportion and stability of circulating tumor DNA (ctDNA). In this review, we provide evidence-based clinical practice guidelines for pre-analytical phase procedures of plasma epidermal growth factor receptor gene ( EGFR ) variant testing. Specific recommendations for pre-analytical procedures were proposed based on evidence from the literature and our experimental data. Standardization of pre-analytical procedures can improve the analytical performance of cfDNA testing. |
| Databáze: | MEDLINE |
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