Intriguing findings of liver fibrosis following COVID-19.

Autor:	Kolesova O; Departments of Infectology, Rīga Stradiņš University, Riga, Latvia. Oksana.Kolesova@rsu.lv.; Institute of Microbiology and Virology, Joint Laboratory of Immunology and Immunogenetics, Rīga Stradiņš University, 5 Ratsupites Street, Riga, 1067, Latvia. Oksana.Kolesova@rsu.lv., Vanaga I; Departments of Infectology, Rīga Stradiņš University, Riga, Latvia.; Institute of Microbiology and Virology, Joint Laboratory of Immunology and Immunogenetics, Rīga Stradiņš University, 5 Ratsupites Street, Riga, 1067, Latvia.; Riga East Clinical University Hospital, Riga, Latvia., Laivacuma S; Departments of Infectology, Rīga Stradiņš University, Riga, Latvia.; Riga East Clinical University Hospital, Riga, Latvia., Derovs A; Departments of Infectology, Rīga Stradiņš University, Riga, Latvia., Kolesovs A; Departments of Infectology, Rīga Stradiņš University, Riga, Latvia.; Faculty of Education, Psychology, and Art, University of Latvia, Riga, Latvia., Radzina M; Faculty of Medicine, University of Latvia, Riga, Latvia.; Radiology Research Laboratory, Rīga Stradiņš University, Riga, Latvia.; Diagnostic Radiology Institute, Paula Stradina Clinical University Hospital, Riga, Latvia., Platkajis A; Department of Radiology, Rīga Stradiņš University, Riga, Latvia., Eglite J; Institute of Microbiology and Virology, Joint Laboratory of Immunology and Immunogenetics, Rīga Stradiņš University, 5 Ratsupites Street, Riga, 1067, Latvia., Hagina E; Institute of Microbiology and Virology, Joint Laboratory of Immunology and Immunogenetics, Rīga Stradiņš University, 5 Ratsupites Street, Riga, 1067, Latvia., Arutjunana S; Riga East Clinical University Hospital, Riga, Latvia., Putrins DS; Diagnostic Radiology Institute, Paula Stradina Clinical University Hospital, Riga, Latvia., Storozenko J; Departments of Infectology, Rīga Stradiņš University, Riga, Latvia.; Central Laboratory Ltd., Riga, Latvia., Rozentale B; Riga East Clinical University Hospital, Riga, Latvia.; Department of Public Health and Epidemiology, Rīga Stradiņš University, Riga, Latvia., Viksna L; Departments of Infectology, Rīga Stradiņš University, Riga, Latvia.; Riga East Clinical University Hospital, Riga, Latvia.
Jazyk:	angličtina
Zdroj:	BMC gastroenterology [BMC Gastroenterol] 2021 Oct 11; Vol. 21 (1), pp. 370. Date of Electronic Publication: 2021 Oct 11.
DOI:	10.1186/s12876-021-01939-7
Abstrakt:	Background: Studies on a new coronavirus disease (COVID-19) show the elevation of liver enzymes and liver fibrosis index (FIB-4) independently on pre-existing liver diseases. It points to increased liver fibrogenesis during acute COVID-19 with possible long-term consequences. This study aimed to assess liver fibrosis in COVID-19 patients by serum hyaluronic acid (HA) and FIB-4. Methods: The study included the acute COVID-19 group (66 patients, 50% females, mean age 58.3 ± 14.6), the post-COVID group (58 patients in 3-6 months after the recovery, 47% females, mean age 41.2 ± 13.4), and a control group (17 people, 47% females, mean age 42.8 ± 11.0). Ultrasound elastography was performed in the post-COVID and control groups. Results: Sixty-five percent of the acute COVID-19 group had increased FIB-4 (> 1.45), and 38% of patients had FIB-4 ≥ 3.25. After matching by demographics, 52% of acute COVID-19 and 5% of the post-COVID group had FIB-4 > 1.45, and 29% and 2% of patients had FIB-4 ≥ 3.25, respectively. Increased serum HA (≥ 75 ng/ml) was observed in 54% of the acute COVID-19 and 15% of the post-COVID group. In the acute COVID-19 group, HA positively correlated with FIB-4, AST, ALT, LDH, IL-6, and ferritin and negatively with blood oxygen saturation. In the post-COVID group, HA did not correlate with FIB-4, but it was positively associated with higher liver stiffness and ALT. Conclusion: More than half of acute COVID-19 patients had increased serum HA and FIB-4 related to liver function tests, inflammatory markers, and blood oxygen saturation. It provides evidence for the induction of liver fibrosis by multiple factors during acute COVID-19. Findings also indicate possible liver fibrosis in about 5% of the post-COVID group. (© 2021. The Author(s).)
Databáze:	MEDLINE
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