Long-term clinical outcome and satisfaction survey in patients with neurotrophic keratopathy after treatment with cenegermin eye drops or amniotic membrane transplantation.

Autor: Sacchetti M; Department of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy., Komaiha C; Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy., Bruscolini A; Department of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy., Albanese GM; Department of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy., Marenco M; Department of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy., Colabelli Gisoldi RAM; Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy., Pocobelli A; Azienda Ospedaliera San Giovanni Addolorata, Rome, Italy., Lambiase A; Department of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy. alessandro.lambiase@uniroma1.it.
Jazyk: angličtina
Zdroj: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie [Graefes Arch Clin Exp Ophthalmol] 2022 Mar; Vol. 260 (3), pp. 917-925. Date of Electronic Publication: 2021 Oct 11.
DOI: 10.1007/s00417-021-05431-6
Abstrakt: Purpose: Neurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. The purpose of this study is to evaluate the clinical outcomes and patient-reported satisfaction of treatment with amniotic membrane transplantation (AMT) or cenegermin eye drops in patients with NK.
Methods: Clinical charts of patients with NK treated with AMT (group A) or cenegermin eye drops (group B), with at least 12 months of follow-up, were reviewed for demographics, medical history, corneal healing, and disease recurrence. Patient satisfaction was evaluated by a newly developed questionnaire investigating patient's appreciation of treatment of NK (2 items) and satisfaction with NK treatment outcomes (5 items).
Results: At the end of treatment, complete corneal healing was observed in 13/15 (86%) patients in group A and in 23/24 (96%) in group B. At 12 months follow-up, 6/13 patients (46%) in group A and 3/23 patients (13%) in group B showed recurrence of NK (p = 0.037). Survival analysis showed that group B remained recurrence free for a significantly longer period of time than the group A (p = 0.028). Patients in group B showed a significantly higher satisfaction when compared with patients in group A (total score: 65.7 ± 15.7 vs 47.4 ± 12.8, p = 0.003), both in terms of patients' appreciation of treatment (78.3 ± 15.9 vs 52.2 ± 30, p = 0.020) and satisfaction with treatment outcomes (60.7 ± 21 vs 45.4 ± 13.3, p = 0.037).
Conclusions: Treatment of NK with cenegermin was associated with long-term maintenance of corneal integrity and a higher degree of patient satisfaction.
(© 2021. The Author(s).)
Databáze: MEDLINE
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