Chiral recognition via a stereodynamic vanadium probe using the electronic circular dichroism effect in differential Raman scattering.

Autor: Machalska E; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland. agnieszka.kaczor@uj.edu.pl.; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, Krakow 30-348, Poland., Hachlica N; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland. agnieszka.kaczor@uj.edu.pl.; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, Krakow 30-348, Poland., Zajac G; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, Krakow 30-348, Poland.; Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610, Prague, Czech Republic. petr.bour@uochb.cas.cz., Carraro D; Dipartimento di Scienze Chimiche, Università degli Studi di Padova and CIRCC, Padova Unit, 35131 Padova, Italy. cristiano.zonta@unipd.it., Baranska M; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland. agnieszka.kaczor@uj.edu.pl.; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, Krakow 30-348, Poland., Licini G; Dipartimento di Scienze Chimiche, Università degli Studi di Padova and CIRCC, Padova Unit, 35131 Padova, Italy. cristiano.zonta@unipd.it., Bouř P; Institute of Organic Chemistry and Biochemistry, Academy of Sciences, Flemingovo náměstí 2, 16610, Prague, Czech Republic. petr.bour@uochb.cas.cz., Zonta C; Dipartimento di Scienze Chimiche, Università degli Studi di Padova and CIRCC, Padova Unit, 35131 Padova, Italy. cristiano.zonta@unipd.it., Kaczor A; Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, Krakow 30-387, Poland. agnieszka.kaczor@uj.edu.pl.; Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Bobrzynskiego 14, Krakow 30-348, Poland.
Jazyk: angličtina
Zdroj: Physical chemistry chemical physics : PCCP [Phys Chem Chem Phys] 2021 Oct 20; Vol. 23 (40), pp. 23336-23340. Date of Electronic Publication: 2021 Oct 20.
DOI: 10.1039/d1cp03020e
Abstrakt: Intermolecular interactions sensitive to chirality occur in many biological events. We report a complex formation between a versatile vanadium-based probe and a chiral co-ligand monitored via the combination of electronic circular dichroism (ECD) and Raman scattering. This "ECD-Raman" effect was discovered relatively recently and can be measured using a Raman optical activity (ROA) spectrometer. Simulated spectra based on experimental ECD and degree of circularity (DOC) values agree with the observed ones. Sensitive recognition of the chiral enantiopure co-ligand is thus enabled by a combination of resonance of the excitation light with the diastereoisomeric complex, co-ligand complexation, circular dichroism, and polarized Raman scattering from the achiral solvent. Relatively dilute solutions could be detected (10 -4 mol dm -3 ), about 1000× less than is necessary for conventional ROA detection of the pure co-ligand and comparable to concentrations needed for conventional ECD spectroscopy. The results thus show that differential ECD-Raman measurements can be conveniently used to monitor molecular interactions and molecular spectroscopic properties.
Databáze: MEDLINE
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