| Autor: |
Wen D; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China., Dong L; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China., Li K; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China., Du Y; Department of Gastric and Colorectal Surgery, The First Hospital of Jilin University, Changchun 130021, China., Deng R; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China., Feng J; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China., Zhang H; State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.; School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, China.; Department of Chemistry, Tsinghua University, Beijing 100084, China., Wang D; Department of Gastric and Colorectal Surgery, The First Hospital of Jilin University, Changchun 130021, China. |
| Abstrakt: |
Despite bismuth-based energy conversion nanomaterials having attracted extensive attention for nanomedicine, the nanomaterials suffer from major shortcomings including low tumor accumulation, long internal retention time, and undesirable photothermal conversion efficiency (PCE). To combat these challenges, bovine serum albumin and folic acid co-modified Bi 2 Se 3 nanomedicine with rich selenium vacancies (abbreviated as V Se -BS) was fabricated for the second near-infrared (NIR-II) light-triggered photonic hyperthermia. More importantly, selenium vacancies on the crystal planes (0 1 5) and (0 1 11) of V Se -BS with similar formation energies could be distinctively observed via aberration-corrected scanning transmission electron microscopy images. The defect engineering endows V Se -BS with enhanced conductivity, making V Se -BS possess outstanding PCE (54.1%) in the NIR-II biowindow and desirable photoacoustic imaging performance. Tumor ablation studies indicate that V Se -BS possesses satisfactory therapeutic outcomes triggered by NIR-II light. These findings give rise to inspiration for further broadening the biological applications of defect engineering bismuth-based nanomaterials. |
