Polymorphisms of androgens-related genes and idiopathic male infertility in Turkish men.

Autor: Metin Mahmutoglu A; Faculty of Medicine, Department of Medical Biology, Ondokuz Mayis University, Samsun, Turkey., Hurre Dirie S; Faculty of Medicine, Department of Medical Biology, Ondokuz Mayis University, Samsun, Turkey., Hekim N; Faculty of Medicine, Department of Medical Biology, Ondokuz Mayis University, Samsun, Turkey., Gunes S; Faculty of Medicine, Department of Medical Biology, Ondokuz Mayis University, Samsun, Turkey.; Health Sciences Institute, Department of Multidisciplinary Molecular Medicine, Ondokuz Mayis University, Samsun, Turkey., Asci R; Health Sciences Institute, Department of Multidisciplinary Molecular Medicine, Ondokuz Mayis University, Samsun, Turkey.; Faculty of Medicine, Department of Urology, Ondokuz Mayis University, Samsun, Turkey., Henkel R; Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa.; American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, Ohio, USA.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.
Jazyk: angličtina
Zdroj: Andrologia [Andrologia] 2022 Mar; Vol. 54 (2), pp. e14270. Date of Electronic Publication: 2021 Oct 10.
DOI: 10.1111/and.14270
Abstrakt: Androgens, testosterone and dihydrotestosterone (DHT) are endocrine regulators of spermatogenesis and act via androgen receptor (AR). The aim of this study was to investigate the association(s) of AR (CAG repeat length), SRD5A2 (rs523349, V89L) and TNF-α (rs1800629, -308G/A) polymorphisms with idiopathic male infertility in Turkish men. This case-control study consisted of 312 men with idiopathic infertility and 113 fertile men. Polyacrylamide gel electrophoresis (PAGE) or PCR-restriction fragment length polymorphism methods were used for genotyping. The mean AR CAG repeat length was significantly longer in infertile men than in fertile men (p = 0.015). However, there was no significant association between the SRD5A2 genotypes (VV, VL and LL) and the risk of infertility (p = 0.516). The genotype frequency and allele distribution of TNF-α -308G/A polymorphism (GG, GA, AA genotypes and G, A alleles) were not associated with male infertility (p = 0.779 and p = 0.743 respectively). AR CAG repeat expansion might be one of the risk factors for idiopathic male infertility in Turkish men. Further studies investigating the association of male infertility with AR CAG, V89L and -308G/A polymorphisms are warranted to understand the possible associations among them.
(© 2021 Wiley-VCH GmbH.)
Databáze: MEDLINE
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