Chemical composition and anti-Mayaro virus activity of Schinus terebinthifolius fruits.

Autor: Salles TS; Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Meneses MDF; Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Yamamoto KA; Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Sá-Guimarães TE; Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Caldas LA; National Institute of Science and Technology for Structural Biology and Bioimaging, INBEB, Rio de Janeiro, RJ Brazil.; Laboratory of Cellular Ultrastructure Hertha Meyer, Federal University of Rio de Janeiro, Rio de Janeiro, RJ Brazil., Silva JHS; Natural Products Research Institute, IPPN, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., da Silva Ferreira P; Chemistry Department, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil., Amaral ACF; Farmanguinhos-Fiocruz, Rio de Janeiro, Brazil., Ventura JA; Capixaba Research Institute, Rural Technical Assistance and Extension, INCAPER, Espirito Santo, Vitória Brazil., Azevedo RC; Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Kuster RM; Natural Products Research Institute, IPPN, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; Chemistry Department, Federal University of Espírito Santo, Vitória, Espírito Santo, Brazil., Soares MR; Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro, Av. Athos da Silveira Ramos 149 Room A-537, Rio de Janeiro, RJ 21941-909 Brazil., Ferreira DF; Institute of Microbiology, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.; National Institute of Science and Technology for Structural Biology and Bioimaging, INBEB, Rio de Janeiro, RJ Brazil.; Department of Molecular and Structural Biochemistry, North Carolina State University, Raleigh, NC USA.
Jazyk: angličtina
Zdroj: Virusdisease [Virusdisease] 2021 Sep; Vol. 32 (3), pp. 526-534. Date of Electronic Publication: 2021 Jun 04.
DOI: 10.1007/s13337-021-00698-z
Abstrakt: Brazilian traditional medicine has explored the antiviral properties of many plant extracts, including those from the Brazilian pepper tree, Schinus terebinthifolius . In the present study, we investigated the chemical composition and anti-mayaro virus (MAYV) activity of S. terebinthifolius fruit. Extensive virucidal activity (more than 95%) was detected for the ethyl acetate extract and the isolated biflavonoids. From the ethyl acetate extract of Schinus terebinthifolius fruits, two bioflavonoids were isolated ((2S, 2″S)-2,3,2″,3″-tetrahydroamentoflavone and agathisflavone), which showed strong virucidal activity against Mayaro virus. Furthermore, several other compounds like terpenes and phenolics were identified by hyphenated techniques (GC-MS, LC-MS and HPLC-UV), as well as by mass spectrometry. Immunofluorescence assay confirmed antiviral activity and transmission electron microscopy revealed damage in viral particles treated with biflavonoids. The data suggest the direct action of the extract and the biflavonoids on the virus particles. The biflavonoids tetrahydroamentoflavone and agathisflavone had strong virucidal activity and reduced MAYV infection.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13337-021-00698-z.
Competing Interests: Conflict of interestThe authors declare no conflict of interest.
(© Indian Virological Society 2021.)
Databáze: MEDLINE
Externí odkaz: