Rigor and reproducibility in polymer nanoparticle synthesis and characterization.

Autor: Sims KR Jr; Dept. of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Translational Biomedical Science, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA., Maceren JP; Dept. of Chemistry, University of Rochester, Rochester, NY, USA., Strand AI; Dept. of Biomedical Engineering, University of Rochester, Rochester, NY, USA., He B; Dept. of Statistics, University of Rochester, Rochester, NY, USA., Overby C; Dept. of Biomedical Engineering, University of Rochester, Rochester, NY, USA., Benoit DSW; Dept. of Biomedical Engineering, University of Rochester, Rochester, NY, USA.; Materials Science Program, Rochester, NY, USA.; Center for Oral Biology, University of Rochester, Rochester, NY, USA.; Center for Musculoskeletal Research, University of Rochester, Rochester, NY, USA.; Dept. of Chemical Engineering, University of Rochester, Rochester, NY, USA.
Jazyk: angličtina
Zdroj: RSC advances [RSC Adv] 2020; Vol. 10 (5), pp. 2513-2518. Date of Electronic Publication: 2020 Jan 14.
DOI: 10.1039/C9RA10091A
Abstrakt: Standardized process improvement methods and tools were used to enhance the rigor and reproducibility of diblock copolymer nanoparticle (NP) synthesis and characterization. Models linking design parameters with NP characteristics boosted process control for NP synthesis, which may improve translation and commercialization of NP research.
Competing Interests: Conflicts of interest There are no conflicts to declare.
Databáze: MEDLINE