Ameliorative effects of crocin on the inflammation and oxidative stress-induced kidney damages by experimental periodontitis in rat.

Autor: Erdemli Z; Inonu University, Faculty of Medicine, Medical Biochemistry Department, Malatya, Turkey., Erdemli ME; Inonu University, Faculty of Medicine, Medical Biochemistry Department, Malatya, Turkey., Gul M; Inonu University, Faculty of Medicine, Histology and Embryology Department, Malatya, Turkey., Altinoz E; Karabuk University, Faculty of Medicine, Medical Biochemistry Department, Karabuk, Turkey., Gul S; Inonu University, Faculty of Medicine, Histology and Embryology Department, Malatya, Turkey., Kocaman G; Karabuk University, Faculty of Dentistry, Periodontology Department, Karabuk, Turkey., Kustepe EK; Inonu University, Faculty of Medicine, Histology and Embryology Department, Malatya, Turkey., Gozukara Bag H; Inonu University, Faculty of Medicine, Biostatistics Department, Malatya, Turkey.
Jazyk: angličtina
Zdroj: Iranian journal of basic medical sciences [Iran J Basic Med Sci] 2021 Jun; Vol. 24 (6), pp. 825-832.
DOI: 10.22038/ijbms.2021.55875.12499
Abstrakt: Objectives: The present study aimed to investigate the effects of periodontitis on kidneys and the protective role of crocin in periodontitis-induced kidney damage.
Materials and Methods: Ethics committee approval was obtained and 30 Wistar rats were randomly divided into 3 groups of 10 rats: Control (C), Periodontitis (P), and Periodontitis + Crocin (P + Cr). After the treatments, rat kidney tissues were incised under anesthesia and blood samples were collected. Biochemical and histopathological analyses were conducted on the samples.
Results: Malondialdehyde (MDA), total oxidant status (TOS), and oxidative stress index (OSI) increased in P group rat kidney tissues; urea, creatinine, Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin 1β (IL-1β) levels increased in the serum; glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and total antioxidant status (TAS) levels were reduced in rat kidney tissues, and renal histopathology deteriorated. In the P + Cr group, we observed improvements in biochemical and histopathological parameters when compared with the P group.
Conclusion: Periodontitis (P) led to deterioration in oxidative stress parameters and histopathology by increasing the oxidants in kidney tissue. P also led to inflammation in the blood of the rats. Periodontitis + Crocin (P + Cr) administration alleviated the effects of P due to powerful antioxidant anti-inflammatory properties. Cr could be employed as a protective agent in P-induced inflammation and oxidative damage.
Competing Interests: No potential conflicts of interest were reported by the authors. The authors alone are responsible for the content and authoring of the present paper.
Databáze: MEDLINE
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