Proteomics: Concepts and applications in human medicine.

Autor:	Al-Amrani S; Department of Microbiology and Immunology, Sultan Qaboos University, Muscat 123, Oman., Al-Jabri Z; Department of Microbiology and Immunology, Sultan Qaboos University, Muscat 123, Oman., Al-Zaabi A; Department of Human and Clinical Anatomy, Sultan Qaboos University, Muscat 123, Oman., Alshekaili J; Department of Microbiology and Immunology, Sultan Qaboos University Hospital, Muscat 123, Oman., Al-Khabori M; Department of Hematology, Sultan Qaboos University, Muscat 123, Oman. khabori@squ.edu.om.
Jazyk:	angličtina
Zdroj:	World journal of biological chemistry [World J Biol Chem] 2021 Sep 27; Vol. 12 (5), pp. 57-69.
DOI:	10.4331/wjbc.v12.i5.57
Abstrakt:	Proteomics is the complete evaluation of the function and structure of proteins to understand an organism's nature. Mass spectrometry is an essential tool that is used for profiling proteins in the cell. However, biomarker discovery remains the major challenge of proteomics because of their complexity and dynamicity. Therefore, combining the proteomics approach with genomics and bioinformatics will provide an understanding of the information of biological systems and their disease alteration. However, most studies have investigated a small part of the proteins in the blood. This review highlights the types of proteomics, the available proteomic techniques, and their applications in different research fields. Competing Interests: Conflict-of-interest statement: All authors declare no conflict of interest. (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
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