HLA-DRB1 ∗ 16:01 and HLA-DQB1 ∗ 05:02 Alleles Influence the Susceptibility and Progression of Cutaneous Malignant Melanoma.

Autor: Wang X; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s/n, Granada 18014, Spain.; Programa de Doctorado en Biomedicina, Universidad de Granada, Granada, Spain., Almazan F; Programa de Doctorado en Biomedicina, Universidad de Granada, Granada, Spain.; Servicio de Dermatología, Hospital Universitario Clinico San Cecilio (PTS), Av. de la Investigación, s/n, Granada 18016, Spain., Montoyo-Pujol YG; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s/n, Granada 18014, Spain., Martin-Casares A; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s/n, Granada 18014, Spain., Martin A; Servicio de Anatomía Patológica, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s/n, Granada 18014, Spain., Cabrera T; Departamento Bioquímica, Biología Molecular e Inmunología III, Universidad de Granada, Granada, Spain., López-Nevot MA; Servicio de Análisis Clínicos e Inmunología, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas s/n, Granada 18014, Spain.; Departamento Bioquímica, Biología Molecular e Inmunología III, Universidad de Granada, Granada, Spain.; Instituto de Investigación Biosanitaria I ibs. GRANADA, Avda de Madrid 15, Pabellón de Consultas Externas 2, Granada 18012, Spain.
Jazyk: angličtina
Zdroj: Journal of oncology [J Oncol] 2021 Sep 30; Vol. 2021, pp. 3801143. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
DOI: 10.1155/2021/3801143
Abstrakt: Background: The influence of HLA class I and II loci on the susceptibility to melanoma remains an area of intense debate. This study aimed to examine whether the HLA system was related to melanoma susceptibility and prognosis in a southern Spanish population.
Methods: In this study, HLA class I and class II genotyping were performed using polymerase chain reaction sequence-specific oligonucleotides (PCR-SSO) in 237 Spanish melanoma patients and 636 ethnically matched controls. Data were analyzed according to the clinical characteristics of the defined subgroups.
Results: Compared to the control group, DRB1 ∗ 16:01 (4% vs. 1.3%, p =0.001, Pc = 0.035, OR = 3.28) and DQB1 ∗ 05:02 (4.9% vs. 2%, p =0.001, Pc = 0.017, OR = 2.54) were positivity associated with the susceptibility to melanoma. Both DRB1 ∗ 16:01 (5.4% vs. 1.3%, p =0.001, Pc = 0.035, OR = 4.46) and DQB1 ∗ 05:02 (6.5% vs. 2%, p =0.001, Pc = 0.017, OR = 3.44) also showed a positive correlation with Breslow thickness >1.5 mm, most notably at an early age of diagnosis (≤58 years), DRB1 ∗ 16:01 (4.2% vs. 1.3%, p =0.001, Pc = 0.035, OR = 3.41) and DQB1 ∗ 05:02 (5.4% vs. 2%, p =0.002, Pc = 0.034, OR = 2.86).
Conclusion: These findings established HLA-DRB1 ∗ 16:01 and HLA-DQB1 ∗ 05:02 loci as melanoma risk factors in the southern Spanish population.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2021 Xu Wang et al.)
Databáze: MEDLINE
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