Association of vitamin A with anemia and serum hepcidin levels in children aged 6 to 59 mo.

Autor: Silva AP; Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Pereira ADS; Escola de Nutrição, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Simões BFT; Centro de Ciências Exatas e Tecnologia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Omena J; Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Cople-Rodrigues CDS; Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., de Castro IRR; Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil., Citelli M; Instituto de Nutrição, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address: martacitelli@gmail.com.
Jazyk: angličtina
Zdroj: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2021 Nov-Dec; Vol. 91-92, pp. 111463. Date of Electronic Publication: 2021 Aug 31.
DOI: 10.1016/j.nut.2021.111463
Abstrakt: Objective: This study evaluates the association of serum retinol, hepcidin levels, and anemia in children.
Methods: This cross-sectional study included 312 children, ages 6 to 59 mo, from Rio de Janeiro, Brazil. The association between hepcidin and retinol levels, hematologic parameters, and body mass index (BMI) was analyzed using a generalized linear model with and without adjustment for C-reactive protein (CRP) level. Logistic regression analysis was used to test anemia as an outcome and serum retinol level as a predictive variable using the odds ratio (OR) function.
Results: Anemia was present in 14.6% of the children, 5.8% presented iron deficiency anemia, and 9.6% had vitamin A deficiency. The increase in serum retinol levels reduced the chances of anemia (OR = 0.13; confidence interval = 0.29-0.59). When CRP level was not adjusted for in the multiple regression analyses, retinol, ferritin levels, and BMI/age were predictors of serum hepcidin levels (β = -3.36, 0.14, 1.02, respectively; P = 0.032). Accordingly, serum retinol levels were inversely associated with CRP levels (β = -0.025 and P < 0.001).
Conclusions: The association between serum retinol and hepcidin levels in children ages 6 to 59 mo seems to be dependent on inflammation. Taken together, the results reinforce the need for the development of further studies to better understand the relationship between vitamin A and anemia of inflammation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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