A geometrically accurate 3 dimensional model of human thermoregulation for transient cold and hot environments.

Autor: Castellani MP; Oak Ridge Institute for Science and Education (ORISE), USA; Biophysics and Biomedical Modeling Division, U.S. Army Research Institute of Environmental Medicine, USA. Electronic address: michael.p.castellani2.ctr@mail.mil., Rioux TP; Biophysics and Biomedical Modeling Division, U.S. Army Research Institute of Environmental Medicine, USA., Castellani JW; Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, USA., Potter AW; Biophysics and Biomedical Modeling Division, U.S. Army Research Institute of Environmental Medicine, USA., Xu X; Biophysics and Biomedical Modeling Division, U.S. Army Research Institute of Environmental Medicine, USA. Electronic address: xiaojiang.xu.civ@mail.mil.
Jazyk: angličtina
Zdroj: Computers in biology and medicine [Comput Biol Med] 2021 Nov; Vol. 138, pp. 104892. Date of Electronic Publication: 2021 Sep 24.
DOI: 10.1016/j.compbiomed.2021.104892
Abstrakt: This paper outlines the development of a finite element human thermoregulatory model using an anatomically and geometrically correct human body model. The finite element body model was constructed from digital Phantoms and is anatomically realistic, including 13 organs and tissues: skin, muscles, fat, bones, heart, lungs, brain, bladder, intestines, stomach, kidneys, liver, and eyes. The model simulates thermal responses through a passive and active system. The passive system describes heat balance within the body and between the skin surface and environment. The active system describes thermoregulatory mechanisms, i.e., vasodilation, vasoconstriction, sweating, and shivering heat production. This model predicts temperature distribution across the body at high spatial resolution, and provides insight into human thermoregulatory responses to non-uniform and transient environments. Predicted temperatures (i.e., core, skin, muscle and fat) at 29 sites were compared with measured values in comfort, hot, and cold conditions. The comprehensive validation shows predictions are accurate and acceptable.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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