Cochlioquinone derivatives produced by coculture of endophytes, Clonostachys rosea and Nectria pseudotrichia.

Autor: Sofian FF; The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan., Suzuki T; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan., Supratman U; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia., Harneti D; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia., Maharani R; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia., Salam S; Faculty of Pharmacy, Universitas Mulawarman, Samarinda 75123, Kalimantan Timur, Indonesia., Abdullah FF; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Garut, Garut 44151, Indonesia., Koseki T; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan., Tanaka K; Graduate School of Arts and Sciences, Iwate University, Morioka, Iwate 020-8550, Japan., Kimura KI; The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan; Graduate School of Arts and Sciences, Iwate University, Morioka, Iwate 020-8550, Japan., Shiono Y; The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan; Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan. Electronic address: yshiono@tds1.tr.yamagata-u.ac.jp.
Jazyk: angličtina
Zdroj: Fitoterapia [Fitoterapia] 2021 Nov; Vol. 155, pp. 105056. Date of Electronic Publication: 2021 Oct 06.
DOI: 10.1016/j.fitote.2021.105056
Abstrakt: Three new meroterpenoid derivatives, furanocochlioquinol (1) and furanocochlioquinone (2), as well as nectrianolin D (3), together with two known biogenetically related compounds 4 and 5 were isolated from a mixed culture of two mangrove-derived fungi, Clonostachys rosea B5-2 and Nectria pseudotrichia B69-1. The structures of 1-3 were deduced based on the interpretation of HRMS and NMR data. Compounds 1-5 exhibited cytotoxicity against human promyelocytic leukemia (HL60) cells with IC 50 values ranging from 0.47 to 10.16 μM.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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