Heart rate variability as a biomarker of functional outcomes in persons with acquired brain injury: Systematic review and meta-analysis.

Autor: Lee Y; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: yejin.l@wustl.edu., Walsh RJ; Program in Occupational Therapy, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: rjwalsh@wustl.edu., Fong MWM; Department of Neurology, Washington University School of Medicine, St. Louis, MO, 63108, USA. Electronic address: wfong@wustl.edu., Sykora M; Department of Neurology, St. John's Hospital, Vienna, Austria; Medical Faculty, Sigmund Freud University, Vienna, Austria; Department of Neurology, Comenius University in Bratislava, Bratislava, Slovakia. Electronic address: mareksykora@yahoo.com., Doering MM; Bernard Becker Medical Library, Washington University School of Medicine, St. Louis, MO, 63110, USA. Electronic address: mmdoering@wustl.edu., Wong AWK; Center for Rehabilitation Outcomes Research, Shirley Ryan AbilityLab, Chicago, IL, 60611, USA; Department of Physical Medicine and Rehabilitation and Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, 60611, USA. Electronic address: wwong@sralab.org.
Jazyk: angličtina
Zdroj: Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2021 Dec; Vol. 131, pp. 737-754. Date of Electronic Publication: 2021 Oct 06.
DOI: 10.1016/j.neubiorev.2021.10.004
Abstrakt: This review aimed to quantify correlations between heart rate variability (HRV) and functional outcomes after acquired brain injury (ABI). We conducted a literature search from inception to January 2020 via electronic databases, using search terms with HRV, ABI, and functional outcomes. Meta-analyses included 16 studies with 906 persons with ABI. Results demonstrated significant associations: Low frequency (LF) (r = -0.28) and SDNN (r = -0.33) with neurological function; LF (r = -0.33), High frequency (HF) (r = -0.22), SDNN (r = -0.22), and RMSSD (r = -0.23) with emotional function; and LF (r = 0.34), HF (r = 0.41 to 0.43), SDNN (r = 0.43 to 0.51), and RMSSD (r = 0.46) with behavioral function. Results indicate that higher HRV is related to better neurological, emotional, and behavioral functions after ABI. In addition, persons with stroke showed lower HF (SMD = -0.50) and SDNN (SMD = -0.75) than healthy controls. The findings support the use of HRV as a biomarker to facilitate precise monitoring of post-ABI functions.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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