Prostate cancer in multi-ethnic Asian men: Real-world experience in the Malaysia Prostate Cancer (M-CaP) Study.

Autor: Lim J; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia., Malek R; Department of Urology, Selayang Hospital, Ministry of Health Malaysia, Selangor, Malaysia., Jr S; Department of Urology, Selayang Hospital, Ministry of Health Malaysia, Selangor, Malaysia., Toh CC; Department of Urology, Selayang Hospital, Ministry of Health Malaysia, Selangor, Malaysia., Sundram M; Department of Urology, Kuala Lumpur Hospital, Ministry of Health Malaysia, Kuala Lumpur, Malaysia., Woo SYY; Department of Urology, Kuala Lumpur Hospital, Ministry of Health Malaysia, Kuala Lumpur, Malaysia., Yusoff NAM; Department of Urology, Kuala Lumpur Hospital, Ministry of Health Malaysia, Kuala Lumpur, Malaysia., Teh GC; Department of Urology, Sarawak General Hospital, Ministry of Health Malaysia, Sarawak, Malaysia., Chui BJT; Department of Urology, Sarawak General Hospital, Ministry of Health Malaysia, Sarawak, Malaysia., Ngu IS; Department of Urology, Sarawak General Hospital, Ministry of Health Malaysia, Sarawak, Malaysia., Thevarajah S; Department of Urology, Queen Elizabeth Hospital, Ministry of Health Malaysia, Kota Kinabalu, Malaysia., Koh WJ; Department of Urology, Queen Elizabeth Hospital, Ministry of Health Malaysia, Kota Kinabalu, Malaysia., Lee SB; Department of Urology, Penang Hospital, Ministry of Health Malaysia, Penang, Malaysia., Khoo SC; Department of Urology, Penang Hospital, Ministry of Health Malaysia, Penang, Malaysia., Teoh BW; Department of Urology, Penang Hospital, Ministry of Health Malaysia, Penang, Malaysia., Zainal R; Department of Surgery, Sultanah Bahiyah Hospital, Ministry of Health Malaysia, Alor Setar, Malaysia., Tham TM; Department of Surgery, Sultanah Bahiyah Hospital, Ministry of Health Malaysia, Alor Setar, Malaysia., Omar S; Department of Urology, Sultanah Aminah Hospital, Ministry of Health Malaysia, Johor Bahru, Malaysia., Nasuha NA; Department of Surgery, Raja Perempuan Zainab II Hospital, Ministry of Health Malaysia, Kota Bahru, Malaysia., Akaza H; Strategic Investigation on Comprehensive Cancer Network, Interfaculty Initiative in Information Studies / Graduate School of Interdisciplinary Information, University of Tokyo, Tokyo, Japan., Ong TA; Department of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2021 Nov; Vol. 10 (22), pp. 8020-8028. Date of Electronic Publication: 2021 Oct 09.
DOI: 10.1002/cam4.4319
Abstrakt: Prostate cancer is the third most common cancer in Malaysia with the lifetime risk of 1 in 117 men. Here, we initiated a longitudinal Malaysia Prostate Cancer (M-CaP) Study to investigate the clinical and tumour characteristics, treatment patterns as well as disease outcomes of multi-ethnic Asian men at real-world setting. The M-CaP database consisted of 1839 new patients with prostate cancer diagnosed between 2016 and 2018 from nine public urology referral centres across Malaysia. Basic demographic and clinical parameters, tumour characteristics, primary treatment, follow-up and vital status data were retrieved prospectively from the hospital-based patients' case notes or electronic medical records. Primary endpoints were overall survival (OS) and biochemical progression-free survival (bPFS). The median age at diagnosis of M-CaP patients was 70 years (interquartile range, IQR 65-75). Majority of patients were Chinese (831, 45.2%), followed by Malays (704, 38.3%), Indians (124, 6.7%) and other races (181, 9.8%). The median follow-up for all patients was 23.5 months (IQR 15.9-33.6). Although 58.1% presented with late-stage cancer, we observed ethnic and geographic disparities in late-stage prostate cancer diagnosis. Curative radiotherapy and primary androgen deprivation therapy were the most common treatment for stage III and stage IV diseases, respectively. The median OS and bPFS of stage IV patients were 40.1 months and 19.2 months (95% CI 17.6-20.8), respectively. Late stage at presentation remains a challenge in multi-ethnic Asian men. Early detection is imperative to improve treatment outcome and survival of patients with prostate cancer.
(© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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