| Autor: |
Olanipekun BE; Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology (IICT), Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.; Department of Chemical, Geological and Physical Sciences, Kwara State University Malete, Malete, Kwara State, Nigeria., Ponnapalli MG; Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology (IICT), Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Patel HK; Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology (IICT), Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Munipalle K; Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology (IICT), Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Shaik K; Centre for Natural Products and Traditional Knowledge, Indian Institute of Chemical Technology (IICT), Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India. |
| Abstrakt: |
A series of new phenyl acetylene and isoxazole analogues of arjunolic acid were designed, synthesized and evaluated (3 - 8 ) for their tyrosinase and alpha glucosidase inhibitory potential. All the tested analogues exhibited stronger inhibitory activity than the standard drug or parent compound. Of these, compound ( 7 ) displayed the most potent tyrosinase inhibitory action with IC 50 (14.3 ± 7.6) of about three folds more than the standard drug, kojic acid (41.5 ± 1.0). Further, compound ( 8 ) (14.5 ± 0.15) possessed the potent alpha glucosidase inhibitory action with IC 50 value comparable to that of standard, acarbose (10.4 ± 0.06). Henceforth, compounds ( 7 ) and ( 8 ) are promising candidates for further studies. |
