Copper nanowire embedded hypromellose: An antibacterial nanocomposite film.

Autor: Bagchi B; Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London W1W 7TS, UK; Nanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London WC1E 7JE, UK., Salvadores Fernandez C; Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London W1W 7TS, UK; Nanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London WC1E 7JE, UK., Bhatti M; UCL Department of Civil, Environmental and Geomatic Engineering, London WC1E 6BT, UK., Ciric L; UCL Department of Civil, Environmental and Geomatic Engineering, London WC1E 6BT, UK., Lovat L; Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London W1W 7TS, UK., Tiwari MK; Wellcome/EPSRC Centre for Interventional and Surgical Sciences (WEISS), University College London, London W1W 7TS, UK; Nanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London WC1E 7JE, UK. Electronic address: m.tiwari@ucl.ac.uk.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2022 Feb 15; Vol. 608 (Pt 1), pp. 30-39. Date of Electronic Publication: 2021 Sep 25.
DOI: 10.1016/j.jcis.2021.09.130
Abstrakt: The present work reports a novel antibacterial nanocomposite film comprising of copper nanowire impregnated biocompatible hypromellose using polyethylene glycol as a plasticiser. Detailed physico-chemical characterization using X-ray diffraction, Fourier transform infrared spectroscopy, UV-Visible spectroscopy and electron microscopy shows uniform dispersion of copper nanowire in the polymer matrix without any apparent oxidation. The film is flexible and shows excellent antibacterial activity against both Gram positive and negative bacteria at 4.8 wt% nanowire loading with MIC values of 400 µg/mL and 500 µg/mL for E. coli and S. aureus respectively. Investigation into the antibacterial mechanism of the nanocomposite indicates multiple pathways including cellular membrane damage caused by released copper ions and reactive oxygen species generation in the microbial cell. Interestingly, the film showed good biocompatibility towards normal human dermal fibroblast at minimum bactericidal concentration (MBC). Compared to the copper nanoparticles reported earlier in vitro studies, this low cytotoxicity of copper nanowires is due to the slow dissolution rate of the film and production of lower amount of ROS producing Cu 2+ ions. Thus, the study indicates a strong potential for copper nanowire-based composites films in broader biomedical and clinical applications.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021. Published by Elsevier Inc.)
Databáze: MEDLINE
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