Liver function as a predictor of mortality in COVID-19: A retrospective study.

Autor:	Salık F; Gazi Yaşargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: fikretsalik@gmail.com., Uzundere O; Gazi Yaşargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: osmanuzundere@gmail.com., Bıçak M; Gazi Yaşargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: drmustafabicak@gmail.com., Akelma H; Gazi Yaşargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: hakanakelma@hotmail.com., Akgündüz M; Gazi Yaşargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: maentri@outlook.com., Korhan Z; Gazi Yaşargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: korhanzeki@gmail.com., Kandemir D; Gazi Yaşargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: denizkande@gmail.com., Kaçar CK; Gazi Yaşargil Training and Research Hospital, Anesthesiology and Reanimation Clinic, Diyarbakir 21010, Turkey. Electronic address: cem.kacar@hotmail.com.
Jazyk:	angličtina
Zdroj:	Annals of hepatology [Ann Hepatol] 2021 Dec; Vol. 26, pp. 100553. Date of Electronic Publication: 2021 Oct 06.
DOI:	10.1016/j.aohep.2021.100553
Abstrakt:	Introduction and Objectives: In many studies, varying degrees of liver damage have been reported in more than half of the COVID-19 patients. The aim of this study is to determine the effect of liver biochemical parameters abnormality on mortality in critical COVID-19 patients who have been followed in the ICU since the beginning of the pandemic process. Materials and Methods: In this study 533 critical patients who admitted to the ICU due to COVID-19 were included. The patients were divided into three groups according to their ALT, AST, and total bilirubin levels at their admission to the ICU. Group 1 was formed of patients with normal liver biochemical parameters values; Group 2 was formed of patients with liver biochemical parameters abnormality; Group 3 was formed of patients with liver injury. Results: 353 (66.2%) of all patients died. Neutrophil, aPTT, CRP, LDH, CK, ALT, AST, bilirubin, procalcitonin and ferritin values in Group 2 and Group 3 were found to be statistically significantly higher than Group 1. It was detected that the days of stay in ICU of the patients in Group 1 was statistically significantly longer than others group. It was found that the patients in Groups 2 and 3 had higher total, 7-day, and 28-day mortality rates than expected. Conclusions: The study showed that liver disfunction was associated with higher mortality and shorter ICU occupation time. Competing Interests: Conflicts of interest The authors declare that they have no conflict of interest. (Copyright © 2021 Fundación Clínica Médica Sur, A.C. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze:	MEDLINE
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