Evaluation of a Risk-Stratified, Heparin-Based, Obstetric Thromboprophylaxis Protocol.

Autor:	Lu MY; Center for Women's Reproductive Health, the Department of Obstetrics and Gynecology, and the Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama; Novant Health Maternal-Fetal Medicine, Charlotte, North Carolina; the Department of Otolaryngology, University of Mississippi Medical Center, Jackson, Mississippi; the Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center New Orleans, New Orleans, Louisiana; the Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, North Carolina; and the University of Alabama at Birmingham School of Medicine, Birmingham, Birmingham, Alabama., Blanchard CT, Ausbeck EB, Oglesby KR, Page MR, Lazenby AJ, Cozzi GD, Muñoz Rogers RD, Bushman ET, Kaplan ER, Ruzic MF, Mahalingam M, Dunk S, Champion M, Casey BM, Tita AT, Kim DJ, Szychowski JM, Subramaniam A
Jazyk:	angličtina
Zdroj:	Obstetrics and gynecology [Obstet Gynecol] 2021 Oct 01; Vol. 138 (4), pp. 530-538.
DOI:	10.1097/AOG.0000000000004521
Abstrakt:	Objective: To evaluate outcomes before and after implementation of a risk-stratified heparin-based obstetric thromboprophylaxis protocol. Methods: We performed a retrospective cohort study of all patients who delivered at our tertiary care center from 2013 to 2018. Deliveries were categorized as preprotocol (2013-2015; no standardized heparin-based thromboprophylaxis) and postprotocol (2016-2018). Patients receiving outpatient anticoagulation for active venous thromboembolism (VTE) or high VTE risk were excluded. Coprimary effectiveness and safety outcomes were postpartum VTEs and wound hematomas, respectively, newly diagnosed after delivery and up to 6 weeks postpartum. Secondary outcomes were other wound or bleeding complications, including unplanned surgical procedures (eg, hysterectomies, wound explorations) and blood transfusions. Outcomes were compared between groups, and adjusted odds ratios (aORs) and 95% CIs were calculated using the preprotocol group as reference. Results: Of 24,229 deliveries, 11,799 (49%) occurred preprotocol. Although patients were more likely to receive heparin-based prophylaxis postprotocol (15.6% vs 1.2%, P<.001), there was no difference in VTE frequency between groups (0.1% vs 0.1%, odds ratio 1.0, 95% CI 0.5-2.1). However, patients postprotocol experienced significantly more wound hematomas (0.7% vs 0.4%, aOR 2.34, 95% CI 1.54-3.57), unplanned surgical procedures (aOR 1.29, 95% CI 1.06-1.57), and blood transfusions (aOR 1.34, 95% CI 1.16-1.55). Conclusion: Risk-stratified heparin-based thromboprophylaxis in a general obstetric population was associated with increased wound and bleeding complications without a complementary decrease in postpartum VTE. Guidelines recommending this strategy should be reconsidered. Competing Interests: Financial Disclosure The authors did not report any potential conflicts of interest. (Copyright © 2021 by the American College of Obstetricians and Gynecologists. Published by Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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