The Toxic Effect of Silver Nanoparticles on Nerve Cells: A Systematic Review and Meta-Analysis.

Autor:	Janzadeh A; Radiation Biology Research Center, Iran University of Medical Sciences, Tehran, Iran., Hamblin MR; Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA.; Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, South Africa., Janzadeh N; Occupational Medicine Research Center (OMRC), Iran University of Medical Sciences (IUMS), Tehran, Iran., Arzani H; Department of Medical Physics and Biomedical Engineering, Shahid Beheshti University of Medical Sciences, Tehran, Iran., MahsaTashakori-Miyanroudi; Department of Medical Physiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran., Yousefifard M; Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. yousefifard.M@iums.ac.ir., Ramezani F; Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran. ramezani.f@iums.ac.ir.
Jazyk:	angličtina
Zdroj:	Reviews of environmental contamination and toxicology [Rev Environ Contam Toxicol] 2021; Vol. 257, pp. 93-119.
DOI:	10.1007/398_2021_67
Abstrakt:	Despite the increasing use of silver nanoparticles in medical sciences, published studies on their interaction with nerve cells and evaluation of risks are dispersed. This systematic review and meta-analysis could be used to devise safety guidelines for the use of silver nanoparticles in industry and medicine to reduce adverse effects on the CNS.After extensive searches, the full text of 30 related studies was reviewed and data mining completed. Data were analyzed by calculating the mean of different ratios between treated and untreated groups. Linear regression between variables was evaluated by meta-regression. Subgroup analysis was also performed due to heterogeneity.Treatment with silver nanoparticles significantly reduced cell viability (SMD = -1.79%; 95% CI: -2.17 to -1.40; p < 0.0001). Concentration > 0.1 μg/mL could kill neurons, while lower concentration would not (SMD -0.258; 95% CI: -0.821 to 0.305; p = 369). In addition to the concentration, the coating, size of the nanoparticles, and cell type are also factors that influence SNP nerve cell toxicity. Measurement of apoptosis (SMD = 2.21; 95% CI: 1.62 to 2.80; p=0.001) and lactate dehydrogenase release rate (SMD = 0.9; 95% CI: 0.33 to 1.47; p < 0.0001) also confirmed the destructive effect of silver nanoparticles on nerve cells. (© 2021. The Author(s), under exclusive license to Springer Nature Switzerland AG.)
Databáze:	MEDLINE
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