Antiepileptic medicines in men and women with stroke in Sweden, a registry-based study.

Autor: Karlsson Lind L; Health and Medical Care Administration Region Stockholm Stockholm Sweden., von Euler M; Department of Clinical Science and Education, Södersjukhuset Karolinska Institutet Stockholm Sweden.; Department of Medical Sciences, School of Medicine Örebro University Örebro Sweden.
Jazyk: angličtina
Zdroj: Health science reports [Health Sci Rep] 2021 Oct 01; Vol. 4 (4), pp. e405. Date of Electronic Publication: 2021 Oct 01 (Print Publication: 2021).
DOI: 10.1002/hsr2.405
Abstrakt: Background and Aim: To describe the utilization of the first antiepileptic drug (AED) in men and women with previous stroke in a nationwide population.
Methods: Prescription data, patient's age, and sex were collected from the Swedish Drug Register and cross-linked to diagnosis data from the National Patient Register and data from Statistics Sweden. Patients with a first dispensation of an AED after stroke between 1 January 2007 and 31 December 2014 were included.
Results: A total of 10 958 patients with stroke were initiated on AED treatment (51% women, mean age 75 years). Gabapentin (n = 3073, 28%), pregabalin (n = 2476, 22%), carbamazepine (n = 2330, 21%), levetiracetam (n = 1158, 10%), and valproic acid (n = 833, 7%) were the most dispensed AEDs. After stratification by the presence of a neuropathic pain diagnosis, gabapentin, and pregabalin were the most used AEDs. In contrast, after stratification for epilepsy/convulsions diagnosis, carbamazepine and levetiracetam were the most initiated AEDs.
Conclusion: This study suggests that AED is mainly used for neuropathic/poststroke pain and the study shows gabapentin and pregabalin to be the most used AEDs. For epilepsy, carbamazepine and levetiracetam were the most used AEDs in patients with previous stroke.
Competing Interests: The authors declare that they have no conflicts of interest.
(© 2021 The Authors. Health Science Reports published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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