Assessment of the performance of the Brazilian Portuguese Nottingham Health Profile in adult growth hormone deficiency and pulmonary hypertension.

Autor:	Heaney A; Galen Research Ltd, Manchester, UK., de Oliveira RWR; Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Bizzi M; Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Correa RA; Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Corso Pereira M; Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil., Simao Mol S; Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Santana Soares B; Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., McKenna SP; Galen Research Ltd, Manchester, UK.; School of Health Sciences, University of Manchester, Manchester, UK., Ribeiro-Oliveira A Jr; Department of Internal Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Jazyk:	angličtina
Zdroj:	F1000Research [F1000Res] 2020 Dec 04; Vol. 9, pp. 1399. Date of Electronic Publication: 2020 Dec 04 (Print Publication: 2020).
DOI:	10.12688/f1000research.27748.2
Abstrakt:	Background: The Nottingham Health Profile (NHP) is a generic measure of perceived distress that has been used widely as an outcome measure in clinical practice and trials. The availability of two Brazilian datasets provided the opportunity to assess the psychometric performance of the NHP in different populations - adult growth hormone deficiency (GHD) and pulmonary hypertension (PH). The purpose of the study was to see how valuable the NHP could be in assessing outcomes in diseases where no disease-specific measures are available. Methods: Secondary analyses were performed with NHP data. Patients diagnosed with adult GHD or PH were administered the NHP during clinic visits on two occasions, two weeks apart. A disease-specific measure of quality of life (QoL) was also administered to the relevant sample of patients on each occasion. Results: The psychometric properties of the NHP were good for both disease groups. As expected, both samples reported high scores on energy level, the PH sample scored high on physical functioning and the GHD sample on emotional reactions. For both samples, most of the NHP sections were able to distinguish between groups of respondents with different ratings of perceived general health. While most sections of the NHP were relatively highly correlated with the QoL measures, pain and sleep did not seem to be important predictors of QoL in either of the samples. Conclusions: The use of the NHP in adult GHD and PH populations in Brazil is not recommended as there are high-quality disease-specific measures available for each disease. However, where no disease-specific measures are available, the NHP can provide good descriptive information of the impact of disease on different patient populations. Competing Interests: Competing interests: AH and SPM are employees of Galen Research Ltd., which is the copyright holder of the NHP, QoL-AGHDA and CAMPHOR. ARO Jr is an employee of Ipsen Bioscience in Cambridge/MA, US. (Copyright: © 2021 Heaney A et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu