Measuring Activated Clotting Time during Cardiac Catheterization and PCI: The Effect of the Sampling Site.

Autor: Heemelaar JC; Department of Cardiology, Northwest Clinics, Alkmaar, Netherlands., Berkhout T; Department of Cardiology, Northwest Clinics, Alkmaar, Netherlands., Heestermans AACM; Department of Cardiology, Northwest Clinics, Alkmaar, Netherlands., Zant JC; Department of Clinical Chemistry, Northwest Clinics, Alkmaar, Netherlands., de Vos AMJ; Department of Cardiology, Catharina Hospital, Eindhoven, Netherlands., Verouden NJW; Department of Cardiology, Amsterdam University Medical Center, Amsterdam, Netherlands., Dirksen MT; Department of Cardiology, Northwest Clinics, Alkmaar, Netherlands., van Ramshorst J; Department of Cardiology, Northwest Clinics, Alkmaar, Netherlands.
Jazyk: angličtina
Zdroj: Journal of interventional cardiology [J Interv Cardiol] 2021 Sep 11; Vol. 2021, pp. 4091289. Date of Electronic Publication: 2021 Sep 11 (Print Publication: 2021).
DOI: 10.1155/2021/4091289
Abstrakt: Results: In 100 patients (mean age 67.1, 65% male), no significant differences were observed in ACT values obtained from the guiding catheter and arterial sheath (mean difference (MD) -18.3 s; standard deviation (SD) 96 s; P =0.067). Contrarily, ACT values obtained from the intravenous line were significantly lower as compared to values obtained from the guiding catheter (MD 25.7 s; SD 75.5; P =0.003) and arterial sheath (MD 39 s; SD 102.8; P < 0.001). Furthermore, ACT measurements from the arterial sheath showed a statistically significant proportional bias when compared to the other sampling sites (sheath vs. catheter, r  = 0.761, P =0.001; sheath vs. IVL, r  = 1.013, P < 0.001).
Conclusions: The present study shows statistical significance and possibly clinically relevant variations between ACT measurements from different sample sites. Bias in ACT measurements may be minimized by using uniform protocols for ACT measurement during cardiac catheterization.
Competing Interests: The authors have no conflicts of interest to declare.
(Copyright © 2021 J. C Heemelaar et al.)
Databáze: MEDLINE
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