Neurobehavioral responses in swiss albino mice induced by an aqueous leaf extract from a medicinal plant named Heliotropium incanum Ruiz & Pav.
| Autor: | Singha HA; Assam University, Silchar, Assam, India 788011., Sengupta M; Assam University, Silchar, Assam, India 788011., Bawari M; Assam University, Silchar, Assam, India 788011. |
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| Jazyk: | angličtina |
| Zdroj: | Bioinformation [Bioinformation] 2020 Sep 30; Vol. 16 (9), pp. 679-687. Date of Electronic Publication: 2020 Sep 30 (Print Publication: 2020). |
| DOI: | 10.6026/97320630016679 |
| Abstrakt: | It is of interest to examine the adverse neuro-behavioural responses on mice treated with the aqueous crude extract of Heliotropium incanum (AEHI), which were evaluated using various behavioral paradigms. On the basis of median lethal dose value, doses of AEHI were chosen to be 150mg/kg and 440mg/kg for further experiment. Four groups comprising of five mice each were divided for the 14 days experiment. Group I, the control group, received distilled water; Group II and III received AEHI (150 mg/kg body weight and 440 mg/kg body weight) respectively; Group IV received standard drugs, Diazepam/Fluoxetine, administered orally. On administration of AEHI, it was revealed that dose 440 mg/kg showed less exploration activity in the hole board test; decrease in the number of squares crossed in locomotory test, time period in the open arm in the plus maze test was significantly reduced and the immobility time was significantly extended in comparison to control and standard drugs. The microscopic study of brain revealed damaged hippocampus along with nerve cells degeneration. Consequently, the results concluded that the outcome of the AEHI produced evidences for the anxiogenic activity in mice. (© 2020 Biomedical Informatics.) |
| Databáze: | MEDLINE |
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