Biomimetic amphiphilic FAAP NPs nanoparticles: Synthesis, characterization and antivirus activity.

Autor: Li XH; State Key Laboratory of Agricultural Microbiology/College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China; College of Pharmaceutical Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, PR China., Zhang Z; College of Pharmaceutical Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, PR China; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. Electronic address: 392073683@qq.com., Ma X; College of Pharmaceutical Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, PR China., Guo ZH; College of Pharmaceutical Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, PR China., Ban X; Faculty of Science, Dalhousie University, PR China., Tian Z; DAlian Medical University, Dalian 116000, PR China., Zhao L; College of Pharmaceutical Engineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, Henan Province, PR China. Electronic address: zhaolisq@163.com., Liu Q; Beijing Institute of Radiation Medicine, Beijing 100850, PR China. Electronic address: liuqiqi@bmi.ac.cn., He Q; State Key Laboratory of Agricultural Microbiology/College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei 430070, PR China. Electronic address: he628@mail.hzau.edu.cn.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2021 Dec; Vol. 101 (Pt A), pp. 108047. Date of Electronic Publication: 2021 Oct 04.
DOI: 10.1016/j.intimp.2021.108047
Abstrakt: Antiviral agents based on natural products have attracted substantial attention in clinical applications for their distinct biological activities,molecular structuralmultiformities, and low biotoxicities. Ferulic acid (FA) with apigenin propaneto form an esterified FA derivative (FAAP).Herein, we designed a CsPbBr3-modified chitosan oligosaccharide, a biomimetic nanoplatform that could load with FAAP. After self-assembly by combining FAAP with CsPbBr3-modified chitosan oligosaccharide (FAAP NPs), the resulting nanoparticles (FAAP NPs) showed high antioxidant and anti-inflammatory activities for enhancing the inhibition of porcineparvovirus.FAAP NPs exhibited no signs of acute toxicity in vitro or in vivo. DPPH and ABST are widely used for quantitative determination of antioxidant capacity. FAAP NPs exhibited excellent DPPH and ABTS radical scavenging abilities. In addition, we found that FAAP NPs inhibited PPV infection-induced PK-15 cell apoptosis, which was associated with regulating antioxidant and anti-inflammatory signaling pathways. Importantly, we showed that FAAP NPs blocked PPV infection-induced mitochondrial apoptosis in PK-15 cells via a p53/BH3 domain molecular-dependent mechanism.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
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