Flash monitor initiation is associated with improvements in HbA 1c levels and DKA rates among people with type 1 diabetes in Scotland: a retrospective nationwide observational study.

Autor: Jeyam A; MRC Institute of Genetics and Cancer (formally known as Institute of Genetic and Molecular Medicine), University of Edinburgh, Edinburgh, UK. anita.jeyam@ed.ac.uk., Gibb FW; Edinburgh Centre for Endocrinology & Diabetes, Royal Infirmary of Edinburgh, Edinburgh, UK., McKnight JA; Western General Hospital, NHS Lothian, Edinburgh, UK., O'Reilly JE; MRC Institute of Genetics and Cancer (formally known as Institute of Genetic and Molecular Medicine), University of Edinburgh, Edinburgh, UK., Caparrotta TM; MRC Institute of Genetics and Cancer (formally known as Institute of Genetic and Molecular Medicine), University of Edinburgh, Edinburgh, UK., Höhn A; MRC Institute of Genetics and Cancer (formally known as Institute of Genetic and Molecular Medicine), University of Edinburgh, Edinburgh, UK., McGurnaghan SJ; MRC Institute of Genetics and Cancer (formally known as Institute of Genetic and Molecular Medicine), University of Edinburgh, Edinburgh, UK., Blackbourn LAK; MRC Institute of Genetics and Cancer (formally known as Institute of Genetic and Molecular Medicine), University of Edinburgh, Edinburgh, UK., Hatam S; MRC Institute of Genetics and Cancer (formally known as Institute of Genetic and Molecular Medicine), University of Edinburgh, Edinburgh, UK., Kennon B; Queen Elizabeth University Hospital, Glasgow, UK., McCrimmon RJ; Division of Molecular and Clinical Medicine, University of Dundee, Dundee, UK., Leese G; Ninewells Hospital, Dundee, UK., Philip S; Grampian Diabetes Research Unit, Diabetes Centre, Aberdeen Royal Infirmary, Aberdeen, UK., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., McKeigue PM; Usher Institute of Population Health Sciences and Informatics, Centre for Population Health Sciences, School of Molecular, Genetic and Population Health Sciences, University of Edinburgh, Edinburgh, UK., Colhoun HM; MRC Institute of Genetics and Cancer (formally known as Institute of Genetic and Molecular Medicine), University of Edinburgh, Edinburgh, UK.; Public Health, NHS Fife, Kirkcaldy, UK.
Jazyk: angličtina
Zdroj: Diabetologia [Diabetologia] 2022 Jan; Vol. 65 (1), pp. 159-172. Date of Electronic Publication: 2021 Oct 07.
DOI: 10.1007/s00125-021-05578-1
Abstrakt: Aims/hypothesis: We assessed the real-world effect of flash monitor (FM) usage on HbA 1c levels and diabetic ketoacidosis (DKA) and severe hospitalised hypoglycaemia (SHH) rates among people with type 1 diabetes in Scotland and across sociodemographic strata within this population.
Methods: This study was retrospective, observational and registry based. Using the national diabetes registry, 14,682 individuals using an FM at any point between 2014 and mid-2020 were identified. Within-person change from baseline in HbA 1c following FM initiation was modelled using linear mixed models accounting for within-person pre-exposure trajectory. DKA and SHH events were captured through linkage to hospital admission and mortality data. The difference in DKA and SHH rates between FM-exposed and -unexposed person-time was assessed among users, using generalised linear mixed models with a Poisson likelihood. In a sensitivity analysis, we tested whether changes in these outcomes were seen in an age-, sex- and baseline HbA 1c -matched sample of non-users over the same time period.
Results: Prevalence of ever-FM use was 45.9% by mid-2020, with large variations by age and socioeconomic status: 64.3% among children aged <13 years vs 32.7% among those aged ≥65 years; and 54.4% vs 36.2% in the least-deprived vs most-deprived quintile. Overall, the median (IQR) within-person change in HbA 1c in the year following FM initiation was -2.5 (-9.0, 2.5) mmol/mol (-0.2 [-0.8, 0.2]%). The change varied widely by pre-usage HbA 1c : -15.5 (-31.0, -4.0) mmol/mol (-1.4 [-2.8, -0.4]%) in those with HbA 1c  > 84 mmol/mol [9.8%] and 1.0 (-2.0, 5.5) mmol/mol (0.1 [-0.2, 0.5]%) in those with HbA 1c  < 54 mmol/mol (7.1%); the corresponding estimated fold change (95% CI) was 0.77 (0.76, 0.78) and 1.08 (1.07, 1.09). Significant reductions in HbA 1c were found in all age bands, sexes and socioeconomic strata, and regardless of prior/current pump use, completion of a diabetes education programme or early FM adoption. Variation between the strata of these factors beyond that driven by differing HbA 1c at baseline was slight. No change in HbA 1c in matched non-users was observed in the same time period (median [IQR] within-person change = 0.5 [-5.0, 5.5] mmol/mol [0.0 (-0.5, 0.5)%]). DKA rates decreased after FM initiation overall and in all strata apart from the adolescents. Estimated overall reduction in DKA event rates (rate ratio) was 0.59 [95% credible interval (CrI) 0.53, 0.64]) after FM vs before FM initiation, accounting for pre-exposure trend. Finally, among those at higher risk for SHH, estimated reduction in event rates was rate ratio 0.25 (95%CrI 0.20, 0.32) after FM vs before FM initiation.
Conclusions/interpretation: FM initiation is associated with clinically important reductions in HbA 1c and striking reduction in DKA rate. Increasing uptake among the socioeconomically disadvantaged offers considerable potential for tightening the current socioeconomic disparities in glycaemia-related outcomes.
(© 2021. The Author(s).)
Databáze: MEDLINE
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