Antenatal steroids and neurodevelopment in 12-year-old children born extremely preterm.

Autor: Kochukhova O; Departments of Women's and Children's Health, Uppsala University, Sweden.; Departments of Psychology, Uppsala University, Sweden., Fredriksson Kaul Y; Departments of Women's and Children's Health, Uppsala University, Sweden., Johansson M; Departments of Women's and Children's Health, Uppsala University, Sweden., Montgomery C; Departments of Women's and Children's Health, Uppsala University, Sweden., Holmström G; Departments of Neuroscience/Ophthamology, Uppsala University, Sweden., Strand Brodd K; Departments of Women's and Children's Health, Uppsala University, Sweden.; Centre for Clinical Research Sörmland, Uppsala University, Sweden., Hellström-Westas L; Departments of Women's and Children's Health, Uppsala University, Sweden.
Jazyk: angličtina
Zdroj: Acta paediatrica (Oslo, Norway : 1992) [Acta Paediatr] 2022 Feb; Vol. 111 (2), pp. 314-322. Date of Electronic Publication: 2021 Oct 28.
DOI: 10.1111/apa.16140
Abstrakt: Aim: To investigate neurodevelopmental outcome in 12-year-old children born very preterm in relation to perinatal, neonatal and socioeconomic variables. To examine whether previously described positive effects of antenatal steroids on cognition persist at 12 years.
Methods: Prospective cohort, 78 children with gestational ages 22.7-31.9 weeks, born in 2004-2007 and examined at 12 years of age with cognitive, motor and visual motor integration tasks and compared to an age-matched control group (n = 50). Two preterm subgroups were studied: very preterm children (28-31 gestational weeks, n = 53) and extremely preterm children (22-27 gestational weeks, n = 25).
Results: The preterm children had significantly lower scores on all cognitive, motor and visual motor integration tasks than the controls. Gestational age and maternal education influenced associations differently in the two preterm subgroups. Also, severe retinopathy of prematurity demonstrated strong associations to outcome. In the extremely preterm group, administration of antenatal steroids was associated with better cognition, basic attention, word generation and motor skills.
Conclusion: At 12 years of age, very preterm children born in the 2000s still have deficits across several neurodevelopmental domains compared to term-born peers. Administration of antenatal steroids has long-lasting associations to cognition and motor skills in extremely preterm-born children.
(© 2021 The Authors. Acta Paediatrica published by John Wiley & Sons Ltd on behalf of Foundation Acta Paediatrica.)
Databáze: MEDLINE
Externí odkaz: