Aortic stenosis and Heyde's syndrome: A comprehensive review.
| Autor: | Lourdusamy D; Internal Medicine, Methodist South Hospital, Memphis, TN 38116, United States. drdennisdhilak@gmail.com., Mupparaju VK; Internal Medicine, Methodist South Hospital, Memphis, TN 38116, United States., Sharif NF; Internal Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, United States., Ibebuogu UN; Cardiovascular Diseases, University of Tennessee Health Science Center, Memphis, TN 38163, United States. |
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| Jazyk: | angličtina |
| Zdroj: | World journal of clinical cases [World J Clin Cases] 2021 Sep 06; Vol. 9 (25), pp. 7319-7329. |
| DOI: | 10.12998/wjcc.v9.i25.7319 |
| Abstrakt: | Heyde's syndrome is an under reported systemic disease of gastrointestinal and cardiac manifestation in older adults. It is characterized by a triad of aortic stenosis, angiodysplasia with bleeding and acquired von Willebrand syndrome. It is characterized by proteolysis of high molecular weight multimers of von Willebrand Factor and loss of platelet mediated homeostasis. Heyde's syndrome is a treatable condition in most cases, especially in the current era of evolution in interventional cardiology and gastroenterology. There are currently no established guidelines in the management of this condition due to paucity of high quality studies, which warrant future trials. High index of suspicion and increasing the awareness of the syndrome among the general practitioners and sub-specialists will improve the diagnostic potential of Heyde's syndrome. Future studies may change the management aspect of Heyde's syndrome and pave a path for drawing specific guidelines and algorithms. The aim of our review article is to summarize the basic pathophysiology, diagnostics and management of Heyde's syndrome with a special attention to Transcatheter aortic valve replacement. Competing Interests: Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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