The Clinical Efficacy and Safety of 11 Commonly Used Treatment Strategies Improving Arrhythmia of CHD in China: A Network Meta-Analysis.

Autor:	Wang T; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Li W; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Huang Q; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Yuan C; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Qu L; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China., Xiao X; The Fifth Medical Center of PLA General Hospital, Beijing, China., Zou W; College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Jazyk:	angličtina
Zdroj:	Frontiers in pharmacology [Front Pharmacol] 2021 Sep 20; Vol. 12, pp. 741716. Date of Electronic Publication: 2021 Sep 20 (Print Publication: 2021).
DOI:	10.3389/fphar.2021.741716
Abstrakt:	Purpose: Arrhythmia which as a common complication of CHD, has a high incidence. At present, more and more anti-arrhythmic drugs are used in clinical practice. However, which drug has the best efficacy and high safety is still unknown. Therefore, we decided to use NMA to solve this problem. Method: We searched CNKI, Wanfang database, VIP database, Pubmed, Embase and Cochrane libraries, and collected all RCTs of arrhythmia of CHD, and used RevMan (5.3) and Stata (13.0) to carry out this NMA. The primary outcome indicator of this study is efficiency; the secondary outcome indicator is the incidence of adverse reactions. Result: A total of 134 RCTs, 13,951 patients, and 11 treatment strategies were included in this NMA. The results show that all treatment strategies can effectively improve the arrhythmia of patients. Among them, PMA+AM, AM+AT, AM+WG have higher effective rates, and PMA+AM, WG+ME, SC+ME have better safety. The effectiveness and safety of the treatment strategies which combined TCM and chemical drugs, are significantly better than that of using chemical drugs alone. Conclusion: The treatment strategy of combination of multiple drugs usually has higher efficiency and safety. PMA+AM seems to be the most recommended treatment strategy. In addition, the rational combination of TCM and chemical drugs may provide potential benefit. Systematic Review Registration : https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42021229693. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Wang, Li, Huang, Yuan, Qu, Xiao and Zou.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu