Cellular anatomy of the mouse primary motor cortex.

Autor:	Muñoz-Castañeda R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Zingg B; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Matho KS; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Chen X; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Allen Institute for Brain Science, Seattle, WA, USA., Wang Q; Allen Institute for Brain Science, Seattle, WA, USA., Foster NN; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Li A; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Narasimhan A; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Hirokawa KE; Allen Institute for Brain Science, Seattle, WA, USA.; Cajal Neuroscience, Seattle, WA, USA., Huo B; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Bannerjee S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Korobkova L; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Park CS; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Park YG; Institute for Medical Engineering and Science, Department of Chemical Engineering, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Bienkowski MS; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.; Department of Physiology and Neuroscience, Zilkha Neurogenetic Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, California, USA., Chon U; Department of Neural and Behavioral Sciences, College of Medicine, Penn State University, Hershey, PA, USA., Wheeler DW; Center for Neural Informatics, Structures and Plasticity, Bioengineering Department and Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA., Li X; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Wang Y; Allen Institute for Brain Science, Seattle, WA, USA., Naeemi M; Allen Institute for Brain Science, Seattle, WA, USA., Xie P; SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Liu L; SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Kelly K; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., An X; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Attili SM; Center for Neural Informatics, Structures and Plasticity, Bioengineering Department and Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA., Bowman I; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Bludova A; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Cetin A; Allen Institute for Brain Science, Seattle, WA, USA., Ding L; SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Drewes R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., D'Orazi F; Allen Institute for Brain Science, Seattle, WA, USA., Elowsky C; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Fischer S; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Galbavy W; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Gao L; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Gillis J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Groblewski PA; Allen Institute for Brain Science, Seattle, WA, USA., Gou L; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Hahn JD; Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA., Hatfield JT; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Hintiryan H; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Huang JJ; Center for Neural Circuits and Sensory Processing Disorders, Zilkha Neurogenetics Institute (ZNI), Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Kondo H; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Kuang X; School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China., Lesnar P; Allen Institute for Brain Science, Seattle, WA, USA., Li X; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Li Y; School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, China., Lin M; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Lo D; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Mizrachi J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Mok S; Allen Institute for Brain Science, Seattle, WA, USA., Nicovich PR; Allen Institute for Brain Science, Seattle, WA, USA.; Cajal Neuroscience, Seattle, WA, USA., Palaniswamy R; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Palmer J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Qi X; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Shen E; Allen Institute for Brain Science, Seattle, WA, USA., Sun YC; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Tao HW; Center for Neural Circuits and Sensory Processing Disorders, Zilkha Neurogenetics Institute (ZNI), Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Wakemen W; Allen Institute for Brain Science, Seattle, WA, USA., Wang Y; SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China.; School of Computer Engineering and Science, Shanghai University, Shanghai, China., Yao S; Allen Institute for Brain Science, Seattle, WA, USA., Yuan J; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Zhan H; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Zhu M; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA., Ng L; Allen Institute for Brain Science, Seattle, WA, USA., Zhang LI; Center for Neural Circuits and Sensory Processing Disorders, Zilkha Neurogenetics Institute (ZNI), Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA., Lim BK; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China.; Division of Biological Science, Neurobiology section, University of California San Diego, San Diego, CA, USA., Hawrylycz M; Allen Institute for Brain Science, Seattle, WA, USA., Gong H; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Gee JC; Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA., Kim Y; Department of Neural and Behavioral Sciences, College of Medicine, Penn State University, Hershey, PA, USA., Chung K; Institute for Medical Engineering and Science, Department of Chemical Engineering, Picower Institute for Learning and Memory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA., Yang XW; Center for Neurobehavioral Genetics, Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA., Peng H; SEU-ALLEN Joint Center, Institute for Brain and Intelligence, Southeast University, Nanjing, China., Luo Q; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Mitra PP; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Zador AM; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA., Zeng H; Allen Institute for Brain Science, Seattle, WA, USA., Ascoli GA; Center for Neural Informatics, Structures and Plasticity, Bioengineering Department and Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA. ascoli@gmu.edu., Josh Huang Z; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. josh.huang@duke.edu.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA. josh.huang@duke.edu., Osten P; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. osten@cshl.edu., Harris JA; Allen Institute for Brain Science, Seattle, WA, USA. jharris@cajalneuro.com.; Cajal Neuroscience, Seattle, WA, USA. jharris@cajalneuro.com., Dong HW; UCLA Brain Research and Artificial Intelligence Nexus, Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. HongWeiD@mednet.ucla.edu.; USC Stevens Neuroimaging and Informatics Institute (INI), Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. HongWeiD@mednet.ucla.edu.
Jazyk:	angličtina
Zdroj:	Nature [Nature] 2021 Oct; Vol. 598 (7879), pp. 159-166. Date of Electronic Publication: 2021 Oct 06.
DOI:	10.1038/s41586-021-03970-w
Abstrakt:	An essential step toward understanding brain function is to establish a structural framework with cellular resolution on which multi-scale datasets spanning molecules, cells, circuits and systems can be integrated and interpreted 1 . Here, as part of the collaborative Brain Initiative Cell Census Network (BICCN), we derive a comprehensive cell type-based anatomical description of one exemplar brain structure, the mouse primary motor cortex, upper limb area (MOp-ul). Using genetic and viral labelling, barcoded anatomy resolved by sequencing, single-neuron reconstruction, whole-brain imaging and cloud-based neuroinformatics tools, we delineated the MOp-ul in 3D and refined its sublaminar organization. We defined around two dozen projection neuron types in the MOp-ul and derived an input-output wiring diagram, which will facilitate future analyses of motor control circuitry across molecular, cellular and system levels. This work provides a roadmap towards a comprehensive cellular-resolution description of mammalian brain architecture. (© 2021. The Author(s).)
Databáze:	MEDLINE
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