HUGO Gene Nomenclature Committee (HGNC) recommendations for the designation of gene fusions.

Autor: Bruford EA; HUGO Gene Nomenclature Committee (HGNC), European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK. elspeth@genenames.org.; Department of Haematology, University of Cambridge School of Clinical Medicine, Cambridge, UK. elspeth@genenames.org., Antonescu CR; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Carroll AJ; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Chinnaiyan A; University of Michigan Medical School, Ann Arbor, MI, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Cree IA; International Agency for Research on Cancer, World Health Organization, Lyon, France., Cross NCP; Faculty of Medicine, University of Southampton, Southampton, UK.; Wessex Regional Genetics Laboratory, Salisbury NHS Foundation Trust, Salisbury, Wiltshire, UK., Dalgleish R; Department of Genetics and Genome Biology, University of Leicester, Leicester, UK., Gale RP; Centre for Haematology Research, Department of Immunology and Inflammation, Imperial College London, London, UK., Harrison CJ; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle upon Tyne, UK., Hastings RJ; The Women's Centre, John Radcliffe Hospital, Oxford University Hospitals Foundation Trust, Oxford, UK., Huret JL; 10 rue des Treilles, Masseuil, Quinçay, France., Johansson B; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Le Beau M; Comprehensive Cancer Center, University of Chicago, Chicago, IL, USA., Mecucci C; Department of Medicine and Surgery, University of Perugia, Perugia, Italy., Mertens F; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden., Verhaak R; Jackson Laboratory for Genomic Medicine, Farmington, CT, USA.; Department of Neurosurgery, Amsterdam University Medical Center, Amsterdam, Netherlands., Mitelman F; Division of Clinical Genetics, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Jazyk: angličtina
Zdroj: Leukemia [Leukemia] 2021 Nov; Vol. 35 (11), pp. 3040-3043. Date of Electronic Publication: 2021 Oct 06.
DOI: 10.1038/s41375-021-01436-6
Abstrakt: Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortcomings. HGNC has worked with the scientific community to determine a new, instantly recognizable and unique separator-a double colon (::)-to be used in the description of fusion genes, and advocates its usage in all databases and articles describing gene fusions.
(© 2021. The Author(s).)
Databáze: MEDLINE
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