Dengue and Zika virus infections in children elicit cross-reactive protective and enhancing antibodies that persist long term.

Autor: Katzelnick LC; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.; Viral Epidemiology and Immunity Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-3203, USA., Zambrana JV; Sustainable Sciences Institute, Managua 14007, Nicaragua., Elizondo D; Sustainable Sciences Institute, Managua 14007, Nicaragua., Collado D; Sustainable Sciences Institute, Managua 14007, Nicaragua., Garcia N; Sustainable Sciences Institute, Managua 14007, Nicaragua., Arguello S; Sustainable Sciences Institute, Managua 14007, Nicaragua., Mercado JC; Sustainable Sciences Institute, Managua 14007, Nicaragua.; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua 16064, Nicaragua., Miranda T; Sustainable Sciences Institute, Managua 14007, Nicaragua., Ampie O; Sustainable Sciences Institute, Managua 14007, Nicaragua., Mercado BL; Sustainable Sciences Institute, Managua 14007, Nicaragua., Narvaez C; Sustainable Sciences Institute, Managua 14007, Nicaragua., Gresh L; Sustainable Sciences Institute, Managua 14007, Nicaragua., Binder RA; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.; Sustainable Sciences Institute, Managua 14007, Nicaragua., Ojeda S; Sustainable Sciences Institute, Managua 14007, Nicaragua., Sanchez N; Sustainable Sciences Institute, Managua 14007, Nicaragua., Plazaola M; Sustainable Sciences Institute, Managua 14007, Nicaragua., Latta K; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, USA., Schiller A; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, USA., Coloma J; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA., Carrillo FB; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA., Narvaez F; Sustainable Sciences Institute, Managua 14007, Nicaragua., Halloran ME; Department of Biostatistics, University of Washington, Seattle, WA 98195-1617, USA.; Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA., Gordon A; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109-2029, USA., Kuan G; Sustainable Sciences Institute, Managua 14007, Nicaragua.; Centro de Salud Sócrates Flores Vivas, Ministry of Health, Managua 12014, Nicaragua., Balmaseda A; Sustainable Sciences Institute, Managua 14007, Nicaragua.; Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministry of Health, Managua 16064, Nicaragua., Harris E; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.
Jazyk: angličtina
Zdroj: Science translational medicine [Sci Transl Med] 2021 Oct 06; Vol. 13 (614), pp. eabg9478. Date of Electronic Publication: 2021 Oct 06.
DOI: 10.1126/scitranslmed.abg9478
Abstrakt: Dengue virus serotypes 1 to 4 (DENV1–4) and Zika virus (ZIKV) are mosquito-borne flaviviruses that induce both virus-specific and broadly reactive antibodies. A first DENV infection is thought to induce antibodies that wane over 2 years to titers that can subsequently enhance severe dengue disease. Secondary DENV infection with a different serotype is thought to induce stable, cross-serotype protective antibodies. Low dengue disease incidence after the recent Zika pandemic led to the hypothesis that ZIKV infection is also transiently cross protective. We investigated antibody kinetics in 4189 children up to 11 years after one and multiple DENV and ZIKV infections in longitudinal cohorts in Nicaragua. We used a DENV inhibition enzyme-linked immunosorbent assay (iELISA), which measures antibodies associated with protection against dengue and Zika disease and with enhancement of dengue disease severity. Unexpectedly, we found that overall DENV iELISA titers stabilized by 8 months after primary DENV infection to a half-life longer than a human life and waned, although gradually, after secondary DENV infection. Similarly, DENV iELISA titers were stable or rose after primary ZIKV infection but declined in individuals with histories of DENV and ZIKV infection. In contrast, kinetics of anti-ZIKV antibodies after ZIKV infection were similar regardless of prior DENV immunity. We observed heterogeneity in DENV iELISA titer, suggesting that individual antibody titer set point, rather than waning, is important for future dengue disease risk. Together, these findings change our understanding of anti-flavivirus antibody kinetics and have implications for measuring vaccine efficacy and for predicting future dengue and Zika outbreaks.
Databáze: MEDLINE
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