Recent strategies driving oral biologic administration.

Autor:	Alotaibi BS; Department of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia., Buabeid M; Department of Clinical Sciences, Ajman University, Ajman, 346, UAE.; Medical and Bio-allied Health Sciences Research Centre, Ajman University, Ajman, United Arab Emirates., Ibrahim NA; Department of Clinical Sciences, Ajman University, Ajman, 346, UAE.; Medical and Bio-allied Health Sciences Research Centre, Ajman University, Ajman, United Arab Emirates., Kharaba ZJ; Department of Clinical Sciences, College of Pharmacy, Al-Ain University of Science and Technology, Abu Dhabi, United Arab Emirates., Ijaz M; Institute of Molecular Biology and Biotechnology, The University of Lahore, Lahore, Pakistan., Murtaza G; Department of Pharmacy, COMSATS University Islamabad, Lahore, 54000, Pakistan.
Jazyk:	angličtina
Zdroj:	Expert review of vaccines [Expert Rev Vaccines] 2021 Dec; Vol. 20 (12), pp. 1587-1601. Date of Electronic Publication: 2021 Oct 21.
DOI:	10.1080/14760584.2021.1990044
Abstrakt:	Introduction: High patient compliance, noninvasiveness, and self-administration are the leading features of vaccine delivery through the oral route. The implementation of swift mass vaccination campaigns in pandemic outbreaks fascinates the use of oral vaccination. This approach can elicit both mucosal and systemic immune responses to protect against infection at the surface of the mucosa. Area Covered: As pathogen entry and spread mainly occurs through the gastrointestinal tract (GIT) mucosal surfaces, oral vaccination may protect and limit disease spread. Oral vaccines target various potential mucosal inductive sites in the GIT, such as the oral cavity, gastric area, and small intestine. Orally delivered vaccines having subunit and nucleic acid pass through various GIT-associated risks, such as the biodegradation of biologics and their reduced absorption. This article presents a summarized review of the existing technologies and prospects for oral vaccination. Expert Opinion: The intestinal mucosa focuses on current approaches, while future strategies target new mucosal sites, i.e. oral cavity and stomach. Recent developments in biologic delivery through the oral route and their potential use in future oral vaccination are mainly considered.
Databáze:	MEDLINE
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