Vascular architectural patterns in clear cell renal cell carcinoma and clear cell papillary renal cell carcinoma.

Autor: Canete-Portillo S; Department of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA., Rodriguez Pena MDC; Department of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA., Wang D; Department of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA., Sanchez DF; Instituto de Patología E Investigación, Asunción, Paraguay., Netto GJ; Department of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA., Magi-Galluzzi C; Department of Pathology, University of Alabama at Birmingham, NP 3545A, 1802 6th Avenue South, Birmingham, AL, 35249-7331, USA. cmagigalluzzi@uabmc.edu.
Jazyk: angličtina
Zdroj: Virchows Archiv : an international journal of pathology [Virchows Arch] 2021 Dec; Vol. 479 (6), pp. 1187-1196. Date of Electronic Publication: 2021 Oct 05.
DOI: 10.1007/s00428-021-03214-2
Abstrakt: Renal cell carcinomas (RCC) are well-vascularized tumors. Although clear cell RCC (CCRCC) show a characteristic vascular network, some cases show overlapping features with other RCC. We aimed to evaluate vascular architectural patterns, microvessel density (MVD), and endothelial cell density (ECD) in CCRCC compared to clear cell papillary RCC (ccpRCC). Thirty-four RCC (17 CCRCC and 17 ccpRCC) were included in the study. CD34 was used to evaluate vascular architectural patterns by microscopic estimation in all cases. CD34, ERG, and Bioquant Osteo 2019 Imaging Analysis Software were used to evaluate MVD and ECD in 17 CCRCC and 15 ccpRCC. Mean MVD was 526.63 in CCRCC vs. 426.18 in ccpRCC (p = 0.16); mean ECD was 937.50 in CCRCC vs. 1060.21 in ccpRCC (p = 0.25). CD34 highlighted four distinct vascular architectural patterns: pseudoacinar, Golgi-like, lacunae, and scattered. Lacunae and pseudoacinar was the most frequent combination in CCRCC; lacunae and Golgi-like was the predominant combination among ccpRCC. Pseudoacinar was most extensive in CCRCC and least in ccpRCC; Golgi-like was predominant in ccpRCC and uncommon in CCRCC. The extent of pseudoacinar and Golgi-like vascular architectural patterns was significantly different between CCRCC and ccpRCC (p < 0.05). Pathologists acquainted with these different vascular architectural patterns may utilize them as an additional tool in the distinction of CCRCC from ccpRCC.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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