Humoral response after SARS-CoV-2 mRNA vaccines in dialysis patients: Integrating anti-SARS-CoV-2 Spike-Protein-RBD antibody monitoring to manage dialysis centers in pandemic times.

Autor: Bachelet T; Clinique Saint-Augustin-CTMR, ELSAN, Bordeaux, France., Bourdenx JP; Clinique Saint-Augustin-CTMR, ELSAN, Bordeaux, France., Martinez C; Clinique Saint-Augustin-CTMR, ELSAN, Bordeaux, France., Mucha S; Clinique Saint-Augustin-CTMR, ELSAN, Bordeaux, France., Martin-Dupont P; Clinique Saint-Augustin-CTMR, ELSAN, Bordeaux, France., Perier V; Clinique Saint-Augustin-CTMR, ELSAN, Bordeaux, France., Pommereau A; Clinique Saint-Augustin-CTMR, ELSAN, Bordeaux, France.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Oct 05; Vol. 16 (10), pp. e0257646. Date of Electronic Publication: 2021 Oct 05 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0257646
Abstrakt: Dialysis patients are both the most likely to benefit from vaccine protection against SARS-CoV-2 and at the highest risk of not developing an immune response. Data from the medical field are thus mandatory. We report our experience with a BNT162b2-mRNA vaccine in a retrospective analysis of 241 dialysis patients including 193 who underwent anti-Spike-Protein-Receptor-Binding-Domain (RBD) IgG analysis. We show that a pro-active vaccine campaign is effective in convincing most patients to be vaccinated (95%) and frequently elicits a specific antibody response (94.3% after two doses and 98.4% after three doses). Only immunocompromised Status is associated with lack of seroconversion (OR 7.6 [1.5-38.2], p = 0.02). We also identify factors associated with low response (last quartile; IgG<500AU/mL): immunocompromised status, age, absence of RAAS inhibitors, low lymphocytes count, high C Reactive Protein; and with high response (high quartile; IgG>7000AU/mL): age; previous SARS-CoV-2 infection and active Cancer. From this experience, we propose a strategy integrating anti-spike IgG monitoring to guide revaccination and dialysis center management in pandemic times.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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