FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients.

Autor: Miroshnikova VV; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation.; National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute, Gatchina, Russian Federation., Polyakova EA; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation., Pobozheva IA; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation.; National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute, Gatchina, Russian Federation., Panteleeva AA; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation.; National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute, Gatchina, Russian Federation., Razgildina ND; National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute, Gatchina, Russian Federation., Kolodina DA; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation., Belyaeva OD; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation., Berkovich OA; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation., Pchelina SN; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation.; National Research Center Kurchatov Institute, Petersburg Nuclear Physics Institute, Gatchina, Russian Federation., Baranova EI; Pavlov First Saint Petersburg State Medical University, St.-Petersburg, Russian Federation.
Jazyk: angličtina
Zdroj: Genetics and molecular biology [Genet Mol Biol] 2021 Sep 29; Vol. 44 (4), pp. e20200441. Date of Electronic Publication: 2021 Sep 29 (Print Publication: 2021).
DOI: 10.1590/1678-4685-GMB-2020-0441
Abstrakt: Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.
Databáze: MEDLINE
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